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Polymeric Scaffolds for Tissue Engineering and Regenerative Medicine

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Smart and Functional Polymers".

Deadline for manuscript submissions: 31 January 2026 | Viewed by 1253

Special Issue Editors


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Guest Editor
Office of Research Administration, Chiang Mai University, Thailand
Interests: polymeric scaffolds; composite materials; wound healing; biomaterials; tissue engineering; biocompatibility; biodegradability; cell proliferation; nanocomposites; inflammation modulation; nanotechnology in scaffolds
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Faculty of Pharmacy, Chiang Mai University, Chiang Mai 50200, Thailand
Interests: polymeric nanoparticles; biodegradable polymers; targeted drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Polymer scaffolds have revolutionized tissue engineering by offering customizable platforms that mimic native extracellular matrix architecture and support cell-driven regeneration. However, critical knowledge gaps persist, limiting their clinical translation and efficacy in regenerative medicine. Addressing these gaps requires interdisciplinary innovation in smart material design, advanced bio-fabrication, and systems biology approaches to bridge the divide between bench-scale promise and clinical reality.

Thus, the special issue focus on the design, fabrication, and biomedical application of polymer-based scaffolds and materials in tissue engineering. With the growing demand for innovative regenerative therapies, biocompatible and functional polymers have become central to scaffold development for repairing or replacing damaged tissues. Moreover, the issue feature cutting-edge research on natural and synthetic polymers, scaffold fabrication techniques, smart biomaterials, and their roles in enhancing cellular behaviour and tissue regeneration. Emphasis has been placed on emerging interdisciplinary approaches, including materials science, nanotechnology, and bioengineering, to address current challenges and future prospects in clinical translation. Topics of interest include but are not limited to, innovations in polymeric materials for tissue regeneration, the development of polymeric scaffolds, and emerging strategies in tissue regeneration and release of therapeutic agents.

Authors are encouraged to clearly communicate the novelty, significance, and potential applications of their work within their manuscripts. We invite you to contribute to this dynamic special issue and join us in advancing the field of bioinspired material.

Dr. Sudarshan Singh
Dr. Chuda Chittasupho
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • polymer scaffolds/composite/nanofibers
  • tissue engineering
  • biodegradable polymers
  • 3D bioprinting
  • hydrogels
  • regenerative medicine
  • smart biomaterials
  • cell-scaffold interaction
  • biofabrication
  • nanostructured polymers

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Published Papers (1 paper)

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Research

11 pages, 958 KB  
Article
Synthetic Electrospun Fiber Matrix in the Management of Acute Wounds Following Excision of Hidradenitis Suppurativa Lesions: A Prospective Pilot Study
by Michael Madueke and Frank Lau
Polymers 2025, 17(19), 2563; https://doi.org/10.3390/polym17192563 - 23 Sep 2025
Viewed by 953
Abstract
Hurley Stage II or III hidradenitis suppurativa (HS) may necessitate surgical excision of diseased skin and subcutaneous fat for symptom control and disease management. These excisions result in open wounds in topographically challenging regions and typically cannot be primarily closed. This study evaluates [...] Read more.
Hurley Stage II or III hidradenitis suppurativa (HS) may necessitate surgical excision of diseased skin and subcutaneous fat for symptom control and disease management. These excisions result in open wounds in topographically challenging regions and typically cannot be primarily closed. This study evaluates the use of a synthetic electrospun fiber matrix (SEFM) as a post-resection regeneration template to accelerate re-granulation and improve subsequent skin graft incorporation. This prospective pilot study enrolled Hurley Stage II or III patients undergoing surgical resection of HS lesions. SEFM was applied to the resulting wounds in conjunction with negative pressure wound therapy (NPWT). Patients were monitored post-operatively for granulation tissue formation and underwent skin grafting once granulation was sufficient. Skin graft incorporation was assessed at follow-up visits. Complications, including graft loss (partial or complete) and infection, were assessed at each encounter. A total of 21 wounds in eight patients met the inclusion criteria and were enrolled. The average time to skin grafting was 14 ± 3.2 days. After grafting, the average graft incorporation was 71 ± 28%. No complications occurred during the study. These initial results indicate that by supporting granulation tissue formation, combined use of SEFM and NPWT may aid in successful engraftment of topographically challenging areas post-HS excision. Full article
(This article belongs to the Special Issue Polymeric Scaffolds for Tissue Engineering and Regenerative Medicine)
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