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3D Printing Polymer Materials and Their Biomedical Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 25 July 2025 | Viewed by 1697

Special Issue Editor


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Guest Editor
School of Medicine and Pharmacy, Ocean University of China, Qingdao, China
Interests: drug delivery system; patient-focused drug development; hot-melt extrusion; 3D printing; quality by design
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

"3D Printing Polymer Materials and Their Biomedical Applications" explores the transformative potential of 3D printing in the medical field, particularly focusing on the use of polymer-based materials.

This collection of research articles delves into innovative approaches for developing biocompatible polymers tailored for various medical and pharmaceutical applications, including the following topics:

Personalized Medicine through 3D-Printed Polymeric Oral Drug Delivery Systems:

  • Investigating the formulation of polymer-based tablets or capsules with customized drug release profiles.
  • Developing patient-specific tablets or capsules that can deliver API or multiple drugs in a controlled manner.
  • Evaluating the dissolution rates, bioavailability, stability, and compatibility of drugs within 3D-printed polymeric carriers.

Transdermal Drug Delivery Devices:

  • Creating 3D-printed microneedle arrays for painless and efficient transdermal drug administration.
  • Studying the mechanical properties and skin penetration efficiency of different polymeric microneedle designs.

Polymer-Based Implants for Localized Drug Delivery:

  • Designing and fabricating 3D-printed implants that release therapeutic agents at the site of implantation.
  • Assessing the long-term drug release kinetics and biocompatibility of polymeric implants.

Polymeric Hydrogels for Sustained Drug Release:

  • Formulating 3D-printed hydrogels that can encapsulate and gradually release drugs over extended periods.
  • Studying the swelling behavior and drug release mechanisms of hydrogel-based delivery systems.

Development of 3D-Printed Buccal and Sublingual Drug Delivery Films:

  • Fabricating thin polymer films for rapid drug absorption through buccal or sublingual routes.
  • Evaluating the dissolution rates, mucoadhesion properties, and patient compliance of 3D-printed films.

Dr. Jiaxiang Zhang
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • patient-specific drug development
  • 3D-printed polymeric carriers
  • transdermal drug delivery
  • 3D-printed buccal and sublingual drug delivery films
  • polymeric hydrogels

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Published Papers (2 papers)

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Research

14 pages, 7321 KiB  
Article
Elastic Properties of Thermoplastic Polyurethane Fabricated Using Multi Jet Fusion Additive Technology
by Karolina Wilińska, Marta Kozuń and Celina Pezowicz
Polymers 2025, 17(10), 1363; https://doi.org/10.3390/polym17101363 - 16 May 2025
Viewed by 322
Abstract
This study investigates the elastic properties of thermoplastic polyurethane (TPU) produced through Multi Jet Fusion (MJF) (HP Inc., Palo Alto, CA, USA) additive technology. TPU specimens of varying thicknesses (0.5 mm to 1.0 mm) and orientations (horizontal, diagonal, vertical) were tested. Results show [...] Read more.
This study investigates the elastic properties of thermoplastic polyurethane (TPU) produced through Multi Jet Fusion (MJF) (HP Inc., Palo Alto, CA, USA) additive technology. TPU specimens of varying thicknesses (0.5 mm to 1.0 mm) and orientations (horizontal, diagonal, vertical) were tested. Results show anisotropic behavior, with diagonally oriented specimens exhibiting the highest elastic properties. The study emphasizes the importance of specifying the method for determining elastic properties in TPU filaments for accurate material selection in applications. The findings highlight that a single-value Young’s modulus is insufficient to describe TPU’s elastic behavior, emphasizing the need for more detailed methodological specification in material datasheets. Additionally, SEM (Thermo Fisher Scientific, Waltham, MA, USA). analysis reveals that build orientation significantly affects failure modes in MJF-printed TPU: vertical prints tend to fracture in a brittle-like manner due to interlayer delamination, whereas horizontal and diagonal orientations promote ductile failure with better layer cohesion. These insights are critical for both accurate material selection and for optimizing TPU parts in functional applications, particularly where mechanical performance under tension is essential. Full article
(This article belongs to the Special Issue 3D Printing Polymer Materials and Their Biomedical Applications)
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23 pages, 8431 KiB  
Article
Improve Solubility and Develop Personalized Itraconazole Dosages via Forming Amorphous Solid Dispersions with Hydrophilic Polymers Utilizing HME and 3D Printing Technologies
by Lianghao Huang, Jingjing Guo, Yusen Li, Weiwei Yang, Wen Ni, Yaru Jia, Mingchao Yu and Jiaxiang Zhang
Polymers 2024, 16(23), 3302; https://doi.org/10.3390/polym16233302 - 26 Nov 2024
Cited by 1 | Viewed by 1039
Abstract
Itraconazole (ITZ), a broad-spectrum triazole antifungal agent, exhibits remarkable pharmacodynamic and pharmacokinetic properties. However, the low solubility of ITZ significantly reduces its oral bioavailability. Furthermore, it has been reported that this medication can result in dose-related adverse effects. Therefore, the objective of this [...] Read more.
Itraconazole (ITZ), a broad-spectrum triazole antifungal agent, exhibits remarkable pharmacodynamic and pharmacokinetic properties. However, the low solubility of ITZ significantly reduces its oral bioavailability. Furthermore, it has been reported that this medication can result in dose-related adverse effects. Therefore, the objective of this study was to enhance the solubility of ITZ through the utilization of various polymers and to manufacture personalized and programmable release ITZ tablets. Five different polymers were selected as water-soluble carriers. Thirty percent w/w ITZ was mixed with seventy percent w/w of the polymers, which were then extruded. A series of physical and chemical characterization studies were conducted, including DSC, PXRD, PLM, and in vitro drug release studies. The results demonstrated that ITZ was dispersed within the polymers, forming ASDs that markedly enhanced its solubility and dissolution rate. Consequently, soluplus® was employed as the polymer for the extrusion of ITZ-loaded filaments, which were subsequently designed and printed. The in vitro drug release studies indicated that the release of ITZ could be regulated by modifying the 3D structure design. Overall, this study found that the combination of HME and 3D printing technologies could represent an optimal approach for the development of personalized and precise drug delivery dosages. Full article
(This article belongs to the Special Issue 3D Printing Polymer Materials and Their Biomedical Applications)
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