Macromolecular Designing for Drug Delivery Systems
A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Chemistry".
Deadline for manuscript submissions: closed (31 December 2021) | Viewed by 22401
Special Issue Editor
Interests: amphiphilic polymers; graft copolymers; molecular brushes; micellization; drug delivery systems
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Studies on well-defined polymers with extraordinary architecture and characteristics have been used to develop macromolecular designing. The (pseudo)living and controlled character of polymerizations leads to the control of basic parameters of polymers, i.e., molecular weights with narrow distribution. Precisely synthesized macromolecules with chain uniformity, composition, topology, and functionality are treated as tailor-made polymers with extremely high performance. The advantageous biocompatibility of functional materials is particularly important for biomedical applications, including tissue engineering, scaffolds, diagnostics, and drug-delivery systems (DDS). The latter require the design of polymeric carriers responsible for drug transport efficiency and its controlled release profile, which is adjusted by controlled particle sizes, hydrophilic/hydrophobic balance, and topology (linear vs. star, brush, and hiperbranched). One of the functions of carriers, based on liposomes, nanospheres, hydrogels, and self-assembling micellar structures with suitable stabilities, is to extend the circulation time in the blood, which increases the effectiveness of the target action. The biological activity of the polymeric system can be increased by the addition of a second bioactive substance, leading to a system with potential application in combined therapy, which enhances treatment efficacy and allows for the restoration of a patient's health or the reduction of the risk of complications.
Prof. Dorota Neugebauer
Guest Editor
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Keywords
- structure design
- polymer carriers
- nonlinear polymers
- amphiphilics
- micellar systems
- loading and release
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