Lignin Composites and Nanocomposites: Preparations and Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: closed (5 September 2023) | Viewed by 1413

Special Issue Editors


E-Mail Website
Guest Editor
Integrated Transformations of Renewable Matter Laboratory (EA TIMR 4297 UTC-ESCOM), Université de Technologie de Compiègne, rue du Dr Schweitzer, 60200 Compiègne, France
Interests: green chemistry; catalysis; alternative technologies (microwave, ultrasound, ball milling, continuous flow, reactive extrusion, 3D printing, etc.); preparation of biobased materials; composites; nanomaterials
Special Issues, Collections and Topics in MDPI journals

E-Mail Website1 Website2
Guest Editor
TIMR, ESCOM/UTC, 1 Allée du Réseau Jean-Marie Buckmaster, 60200 Compiègne, France
Interests: biomass; lignin; green chemistry; organocatalysis; cross-coupling; catalysis; organic synthesis; asymmetric synthesis; nanoparticles; homogeneous catalysis; supported catalysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

With our continued in-depth understanding of the environmental pollution and petro-source crisis, the renewable and degradable properties of biomass materials are being increasingly valued. Lignin, as the second most abundant natural polymer after cellulose, represents a unique renewable material that could be used in a wide range of applications. Moreover, as a byproduct in the pulp and paper industry and biomass refining, lignin is produced in large quantities. Nevertheless, worldwide, only 5% of lignin is explored for high value development, and therefore, there are still numerous challenges and opportunities for the research and development of lignin application.

One of the reasons lignin utilization has been hindered is its heterogenous nature and complex structure, which is additionally impacted by the extraction process and the nature of the biomass. On the other hand, this chemical diversity is also an important asset for lignin that gives it its numerous properties, which, combined with biodegradability and low toxicity, explain the growing interest in lignin bio-based materials. Therefore, lignin is extensively studied as regards its usefulness in adsorbent materials, drug carriers, catalytic materials, phenolic resins, anticorrosion coatings, electrode materials for energy applications, scaffold materials for tissue engineering, and other fields.

The purpose of this Special Issue is to publish a collection of research articles and reviews on the topic of lignin bio-based materials. In this Special Issue, contributions on the production, characterization, and applications of lignin bio-based materials and nanomaterials, as well as composites with other materials or nanomaterials, are welcome.

Prof. Dr. Erwann Guénin
Dr. Vincent Terrasson
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Polymers is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • lignin
  • composite
  • nanomaterials
  • electrode
  • supported catalysis
  • drug carrier
  • tissue engineering

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Research

14 pages, 2206 KiB  
Article
Therapeutic Modulation of Cell Morphology and Phenotype of Diseased Human Cells towards a Healthier Cell State Using Lignin
by Mischa Selig, Kathrin Walz, Jasmin C. Lauer, Bernd Rolauffs and Melanie L. Hart
Polymers 2023, 15(14), 3041; https://doi.org/10.3390/polym15143041 - 14 Jul 2023
Cited by 1 | Viewed by 1032
Abstract
Despite lignin’s global abundance and its use in biomedical studies, our understanding of how lignin regulates disease through modulation of cell morphology and associated phenotype of human cells is unknown. We combined an automated high-throughput image cell segmentation technique for quantitatively measuring a [...] Read more.
Despite lignin’s global abundance and its use in biomedical studies, our understanding of how lignin regulates disease through modulation of cell morphology and associated phenotype of human cells is unknown. We combined an automated high-throughput image cell segmentation technique for quantitatively measuring a panel of cell shape descriptors, droplet digital Polymerase Chain Reaction for absolute quantification of gene expression and multivariate data analyses to determine whether lignin could therapeutically modulate the cell morphology and phenotype of inflamed, degenerating diseased human cells (osteoarthritic (OA) chondrocytes) towards a healthier cell morphology and phenotype. Lignin dose-dependently modified all aspects of cell morphology and ameliorated the diseased shape of OA chondrocytes by inducing a less fibroblastic healthier cell shape, which correlated with the downregulation of collagen 1A2 (COL1A2, a major fibrosis-inducing gene), upregulation of collagen 2A1 (COL2A1, a healthy extracellular matrix-inducing gene) and downregulation of interleukin-6 (IL-6, a chronic inflammatory cytokine). This is the first study to show that lignin can therapeutically target cell morphology and change a diseased cells’ function towards a healthier cell shape and phenotype. This opens up novel opportunities for exploiting lignin in modulation of disease, tissue degeneration, fibrosis, inflammation and regenerative medical implants for therapeutically targeting cell function and outcome. Full article
(This article belongs to the Special Issue Lignin Composites and Nanocomposites: Preparations and Applications)
Show Figures

Graphical abstract

Back to TopTop