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Advanced Polymeric Biomaterials for Drug Delivery Applications

A special issue of Polymers (ISSN 2073-4360). This special issue belongs to the section "Polymer Applications".

Deadline for manuscript submissions: 30 September 2026 | Viewed by 8526

Special Issue Editor

Special Issue Information

Dear Colleagues,

The traditional forms of drug administration are often associated with low efficacy and side effects. Due to this, controlled drug delivery systems (DDSs) began to be designed and customized according to the specific therapeutic compound. DDSs include micro- and nano-sized delivery systems, as well as 2D or 3D hydrogels. Developed DDSs have been revealed to be able to preserve bioactive agents’ safety, increase their efficacy, control their release kinetics, and keep the concentration of the drug within the desired therapeutic range. Moreover, tissue-specific drug delivery, dosing frequency reduction, and drug bioavailability increase were other advantages that allowed us to reduce follow-up care and increase patients’ comfort and compliance. Several polymers have been developed and employed for the development of DDSs. However, at present, challenges still remain and research is moving toward the development of new advanced materials for use in the development of even more effective and tunable DDSs. The present Special Issue welcomes contributions in the form of original research articles, preclinical investigations, or review articles on the broad topic of Advanced Polymeric Biomaterials for DDSs, with a focus on any aspect regarding micro- and nano-sized DDS synthesis methods, including the development of advanced biomaterials, polymeric structure modification and customization, effective production processes, and innovative strategy modifications.

Dr. Nunzia Gallo
Guest Editor

Manuscript Submission Information

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Keywords

  • drug delivery system
  • polymers
  • microparticles
  • nanoparticles
  • biomaterials

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Published Papers (4 papers)

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Research

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20 pages, 5255 KB  
Article
Development and Characterization of Chitosan Microparticles via Ionic Gelation for Drug Delivery
by Zahra Rajabimashhadi, Annalia Masi, Sonia Bagheri, Claudio Mele, Gianpiero Colangelo, Federica Paladini and Mauro Pollini
Polymers 2025, 17(19), 2603; https://doi.org/10.3390/polym17192603 - 26 Sep 2025
Cited by 2 | Viewed by 3092
Abstract
This study explores the formulation of chitosan microparticles through ionic gelation and presents detailed physicochemical characterization, release studies, and the utility and potential uses for drug delivery. Three formulations were prepared under rate-controlled conditions (stirring at 800 rpm and pH maintained at 4.6) [...] Read more.
This study explores the formulation of chitosan microparticles through ionic gelation and presents detailed physicochemical characterization, release studies, and the utility and potential uses for drug delivery. Three formulations were prepared under rate-controlled conditions (stirring at 800 rpm and pH maintained at 4.6) with and without stabilizers to examine the effects of formulation parameters on particle morphology and structural stability. To determine different structural and chemical characteristics, Attenuated Total Reflectance Fourier-Transform Infrared spectroscopy (ATR–FTIR), Scanning Electron Microscopy (SEM), and dynamic light scattering (DLS) were utilized, which confirmed that the particles formed and assessed size distribution and structural integrity. Atomic force microscopy (AFM) was used to quantify surface roughness and potential nanomechanical differences that may derive from the use of different modifiers. Coformulation of bovine serum albumin (BSA) permitted assessment of encapsulation efficiency and drug release capacity. Based on in vitro release evidence, the protein released at a different rate, and the dispersion of formulations under physiological conditions (PBS, pH 7.4, 37 °C) confirmed the differences in stability between formulations. The tunable physical characteristics, mild fabrication conditions, and controlled drug release demonstrated that the chitosan particles could have useful relevance as a substrate for localized drug delivery and as a bioactive scaffold for tissue regenerative purposes. Full article
(This article belongs to the Special Issue Advanced Polymeric Biomaterials for Drug Delivery Applications)
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32 pages, 5511 KB  
Article
Development of Carbohydrate Polyelectrolyte Nanoparticles for Use in Drug Delivery Systems that Cross the Blood–Brain Barrier to Treat Brain Tumors
by Vladimir E. Silant’ev, Mikhail E. Shmelev, Andrei S. Belousov, Fedor O. Trukhin, Nadezhda E. Struppul, Aleksandra A. Patlay, Anna K. Kravchenko, Sergey P. Shchava and Vadim V. Kumeiko
Polymers 2025, 17(12), 1690; https://doi.org/10.3390/polym17121690 - 18 Jun 2025
Cited by 3 | Viewed by 1613
Abstract
The low effectiveness of various brain cancer treatment methods is due to a number of significant challenges. Most of them are unable to penetrate the blood–brain barrier (BBB) when drugs are administered systemically through the bloodstream. Nanoscale particles play a special role among [...] Read more.
The low effectiveness of various brain cancer treatment methods is due to a number of significant challenges. Most of them are unable to penetrate the blood–brain barrier (BBB) when drugs are administered systemically through the bloodstream. Nanoscale particles play a special role among materials capable of binding drug molecules and successfully crossing the BBB. Biopolymeric nanoparticles (NPs) demonstrate excellent biocompatibility and have the remarkable ability to modify the environment surrounding tumor cells, thereby potentially improving cellular uptake of delivery agents. In our research, nanoscale polyelectrolyte complexes (PECs) ranging in size from 56 to 209 nm were synthesized by ionic interaction of the oppositely charged polysaccharides pectin and chitosan. The structural characteristics of these complexes were carefully characterized by infrared (FTIR) and Raman spectroscopy. The immobilization efficiency of antitumor drugs was comprehensively evaluated using UV spectrophotometry. The cytotoxicity of the NPs was evaluated in the U87-MG cell line. The preliminary data indicate a significant decrease in the metabolic activity of these tumor cells. Important details on the interaction of the NPs with an endothelial layer structurally similar to the BBB were obtained by simulating the BBB using a model based on human blood vessels. Our studies allowed us to establish a significant correlation between the kinetic parameters of drug immobilization and the ratio of biopolymer concentrations in the initial compositions, which provides valuable information for future optimization of drug delivery system design. Full article
(This article belongs to the Special Issue Advanced Polymeric Biomaterials for Drug Delivery Applications)
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Review

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58 pages, 10581 KB  
Review
Hydrogels—Advanced Polymer Platforms for Drug Delivery
by Rodica Ene (Vatcu), Andreea-Teodora Iacob, Iuliu Fulga, Maria Luisa Di Gioia, Ionut Dragostin, Ana Fulga, Sangram Keshari Samal and Oana-Maria Dragostin
Polymers 2026, 18(6), 709; https://doi.org/10.3390/polym18060709 - 14 Mar 2026
Cited by 1 | Viewed by 1970
Abstract
Optimizing drug administration remains a central challenge in the development of modern therapies, especially in the context of conditions that require spatiotemporal control of active substance release. In this context, hydrogels have been intensively investigated as polymeric platforms for drug delivery, through their [...] Read more.
Optimizing drug administration remains a central challenge in the development of modern therapies, especially in the context of conditions that require spatiotemporal control of active substance release. In this context, hydrogels have been intensively investigated as polymeric platforms for drug delivery, through their three-dimensional hydrophilic structure, tunable properties, and compatibility with biological environments. This analysis presents an integrated approach to hydrogels used in drug administration, addressing the physicochemical fundamentals, the constitutive polymeric materials, and the mechanisms of response to relevant physiological stimuli. Recent experimental studies have been discussed, which highlight the use of hydrogels based on natural, synthetic, and hybrid polymers for controlled and targeted release, in correlation with various administration routes, including oral, injectable, transmucosal, and topical ones. Advanced functionalization strategies that allow adaptive responses to pH, temperature, glucose, enzymes, and reactive oxygen species are also analyzed. Furthermore, emerging directions integrating hydrogels with biosensors, microdevices, and wireless communication systems for real-time monitoring and on-demand release are highlighted. Overall, the analysis emphasizes the role of smart hydrogels as multifunctional platforms for complex therapeutic strategies while also underlining the current challenges associated with clinical translation and long-term performance. Full article
(This article belongs to the Special Issue Advanced Polymeric Biomaterials for Drug Delivery Applications)
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39 pages, 2314 KB  
Review
Polymer Matrices for Reversible Thermogelling Hydrogels: Principles, Fabrication, and Drug Delivery Prospects
by Victor S. Pyzhov, Elena O. Bakhrushina, Vladimir I. Gegechkori, Valery V. Smirnov, Grigoriy Y. Evzikov, Anna K. Kartashova, Irina M. Zubareva, Ivan I. Krasnyuk, Jr. and Ivan I. Krasnyuk
Polymers 2026, 18(6), 681; https://doi.org/10.3390/polym18060681 - 11 Mar 2026
Cited by 1 | Viewed by 1151
Abstract
This review presents a comprehensive analysis of modern thermosensitive polymer systems for in situ systems (ISSs) which are used for targeted drug delivery in situ. The main classes of polymers used to create “smart” hydrogels that undergo a “sol–gel” phase transition in response [...] Read more.
This review presents a comprehensive analysis of modern thermosensitive polymer systems for in situ systems (ISSs) which are used for targeted drug delivery in situ. The main classes of polymers used to create “smart” hydrogels that undergo a “sol–gel” phase transition in response to a temperature stimulus in the physiological range are considered. Key representatives of thermosensitive matrices are described in detail: synthetic block copolymers (poloxamers, block copolymers of polylactic-co-polyglycolic acid with polyethyleneglycol, etc.) and natural, modified natural, and semi-synthetic polymers (chitosan, including in combination with β-glycerophosphate, xyloglucan, etc.). This paper systematizes the advantages and disadvantages of various thermosensitive systems and highlights the key risks in their pharmaceutical development, including the influence of the nature and concentration of the active pharmaceutical ingredients and excipients on the rheological properties and phase transition temperature. Particular attention is paid to the difference between thermoreversible and irreversible gel-forming systems. Modern in vitro, ex vivo, and in vivo methods for evaluating critical quality parameters of thermosensitive systems, such as gelation temperature and time, gel strength, mucoadhesive properties, and release kinetics, are discussed. The need to develop standardized and biologically relevant methods to improve the reproducibility and success of preclinical studies is emphasized. The review is intended to help researchers to make informed choices about polymer matrices and optimize compositions for successful pharmaceutical development. Full article
(This article belongs to the Special Issue Advanced Polymeric Biomaterials for Drug Delivery Applications)
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