Neuroprotective, Anxiolytic or Antidepressant Activity in Medicinal Plants

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 20 May 2024 | Viewed by 1950

Special Issue Editors

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Guest Editor
Lab de Neuropsicofarmacología, Dirección de Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente Muñiz, Ciudad de México 14370, Mexico
Interests: neuroendocrinology; the pharmacology of central nervous system focus on mental health; the pharmacology of natural products; depression and anxiety; women’s mental health

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Co-Guest Editor
Departamento de Farmacobiología, Centro de Investigación y de Estudios Avanzados IPN (Cinvestav-IPN), Ciudad de México 07360, Mexico
Interests: phytopharmacology; anxiolytics; antidepressants; animal models
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Special Issue Information

Dear Colleagues,

Medicinal plants exert beneficial effects on health. The use of folk medicine as an alternative to treating anxiety, depression, or related mental disorders has become more relevant in recent decades. Few plants have been approved for their safe use; however, it is necessary to provide information on active compounds’ pharmacodynamic and pharmacokinetic properties from different parts of potential medicinal plants with neuroprotectant, antidepressant, or anxiolytic properties.

Studies using behavior analysis in combination with brain tissue analysis can investigate the redox status, neuroinflammation, neuroprotection, neuroplasticity, neurogenesis, or characterization activity of signaling pathways with antidepressant or anxiolytic effects involved in the mechanism of neuroprotection are also welcome. Moreover, reviews on a specific plant family are welcome, highlighting active compounds found in the family and possible mechanisms of action, such as neuroprotective, antidepressant-like, or anxiolytic-like effects.

The material analyzed should contain at least one active compound derived from the extract of a complete plant, in addition to seeds, roots, fruits, leaves, or stems, with a mechanism of action supported by in vivo and in vitro studies.

Dr. Erika Estrada Camarena
Dr. Carolina López-Rubalcava
Guest Editors

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Plants is an international peer-reviewed open access semimonthly journal published by MDPI.

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  • medicinal plants
  • active compounds
  • pharmacodynamic and pharmacokinetic properties
  • plant extracts

Published Papers (1 paper)

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22 pages, 10163 KiB  
Ethnobotanical, Phytochemical, and Pharmacological Properties of the Subfamily Nepetoideae (Lamiaceae) in Inflammatory Diseases
by Nancy Ortiz-Mendoza, Martha Juana Martínez-Gordillo, Emmanuel Martínez-Ambriz, Francisco Alberto Basurto-Peña, María Eva González-Trujano and Eva Aguirre-Hernández
Plants 2023, 12(21), 3752; - 02 Nov 2023
Cited by 2 | Viewed by 1547
Nepetoideae is the most diverse subfamily of Lamiaceae, and some species are well known for their culinary and medicinal uses. In recent years, there has been growing interest in the therapeutic properties of the species of this group regarding inflammatory illnesses. This study [...] Read more.
Nepetoideae is the most diverse subfamily of Lamiaceae, and some species are well known for their culinary and medicinal uses. In recent years, there has been growing interest in the therapeutic properties of the species of this group regarding inflammatory illnesses. This study aims to collect information on traditional uses through ethnobotanical, pharmacological, and phytochemical information of the subfamily Nepetoideae related to inflammatory diseases. UNAM electronic resources were used to obtain the information. The analysis of the most relevant literature was compiled and organised in tables. From this, about 106 species of the subfamily are traditionally recognised to alleviate chronic pain associated with inflammation. Pharmacological studies have been carried out in vitro and in vivo on approximately 308 species belonging to the genera Salvia, Ocimum, Thymus, Mentha, Origanum, Lavandula, and Melissa. Phytochemical and pharmacological evaluations have been performed and mostly prepared as essential oil or high polarity extracts, whose secondary metabolites are mainly of a phenolic nature. Other interesting and explored metabolites are diterpenes from the abietane, clerodane, and kaurane type; however, they have only been described in some species of the genera Salvia and Isodon. This review reveals that the Nepetoideae subfamily is an important source for therapeutics of the inflammatory process. Full article
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