Molecular Mechanisms of Plant Responses to Heavy Metal Stress

A special issue of Plants (ISSN 2223-7747).

Deadline for manuscript submissions: 15 November 2025 | Viewed by 800

Special Issue Editors


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Guest Editor
College of Forestry, Sichuan Agricultural University, Ya'an, China
Interests: tree; heavy metals

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Guest Editor
College of Tree Peony, Henan University of Science and Technology, Luoyang, China
Interests: forest tree genetics and breeding; abiotic stress; plant transgenic; Cd stress

Special Issue Information

Dear Colleagues,

Heavy Metal Pollution: Plant Adaptive Mechanisms and Phytoremediation Strategies.

Heavy metal (HM) pollution poses significant challenges to agricultural and ecosystem health. Understanding the complex physiological, biochemical, and molecular mechanisms by which plants respond to HM stress is essential for selecting appropriate plants that can mitigate metal toxicity. This knowledge is crucial for alleviating soil and water contamination through optimized phytoremediation strategies. Recent research has highlighted adaptive adjustment strategies of plants under HM stress, revealing a range of physiological, biochemical, and molecular responses. However, gaps remain in our understanding of how plants perceive, respond to, and adapt to HM exposure, particularly under multiple stress conditions. Bridging these gaps is vital for developing innovative strategies to enhance plant resilience and productivity in HM-polluted environments.

This research topic aims to compile cutting-edge studies and comprehensive reviews to elucidate plant adaptive strategies under HM stress. The main objectives include exploring plant physiological, biochemical, and molecular responses to HM exposure, understanding mechanisms of HM-induced oxidative stress, and identifying holistic solutions to improve plant recovery capabilities under complex environmental conditions. Specific questions to address include how plants perceive and respond to HM stress at the molecular level, what the key genes and metabolic pathways involved in HM tolerance are, how omics approaches can reveal HM tolerance mechanisms, and how plants epigenetically respond to HM stimuli.

To further understand plant adaptive mechanisms under HM stress, we welcome submissions discussing, but not limited to, the following topics:

  • Characterizing plant uptake, accumulation, distribution, and detoxification processes of HMs, including competition with nutrient uptake;
  • Genome-wide identification, comparison, and evolutionary analysis of plant ion transporter protein (including metal ion transporter protein) families;
  • Clarifying the genetic and molecular basis of plant adaptation to HM accumulation, with a focus on signaling pathways and metabolic adjustments;
  • Utilizing omics methods to reveal mechanisms of plant tolerance to HMs, including tolerance mechanisms in hyperaccumulators and perennial plants (woody species);
  • Investigating mechanisms of HM-induced oxidative stress, the roles of ROS and RNS, and their dependent signaling pathways;
  • Conducting functional validation and in-depth physiological studies of key genes and proteins involved in HM tolerance and stress recovery;
  • Studying plant stress responses to HMs under multiple stress factors or with exogenous substance additions to determine the physiological and molecular mechanisms of plant responses to complex signaling under HM stress.

Dr. Fang He
Dr. Mengxue Niu
Guest Editors

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Keywords

  • heavy metal pollution
  • plant adaptive mechanisms
  • phytoremediation strategies
  • oxidative stress
  • molecular responses
  • genetic tolerance
  • omics approaches

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Published Papers (1 paper)

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Research

22 pages, 5277 KiB  
Article
Cesium Accumulation Patterns and Stress Response in Hydroponic Radish (Raphanus sativus L.): A Physiological–Transcriptomic Study
by Yu-Han Wen, Xi Chen, Ming Sun, Chao-Hui Yang, Meng-Yuan Xu, Feng-Xiang Lai, Si-Qi Fu, Yu-Meng Fan, Xin-Peng Guo, Qun Li and Guo Wu
Plants 2025, 14(12), 1802; https://doi.org/10.3390/plants14121802 - 12 Jun 2025
Viewed by 422
Abstract
The present study systematically investigated the cesium (Cs) enrichment characteristics and physiological responses to Cs exposure in radish (Raphanus sativus L.) seedlings under hydroponic conditions through integrated physiological, biochemical, and transcriptome analyses. The results showed that the Cs content in radish roots, [...] Read more.
The present study systematically investigated the cesium (Cs) enrichment characteristics and physiological responses to Cs exposure in radish (Raphanus sativus L.) seedlings under hydroponic conditions through integrated physiological, biochemical, and transcriptome analyses. The results showed that the Cs content in radish roots, stems, and cotyledons increased progressively with rising Cs concentrations (0.25–2 mM), and Cs mainly accumulated in the cotyledon. The transfer factor (TF) increased by 63.29% (TF = 3.87) as the Cs concentration increased from 0.25 to 2 mM, while the biological concentration factor (BCF) decreased by 72.56% (BCF = 14.87). Severe growth inhibition was observed at 2 mM Cs stress, with biomass reduction reaching 29.73%. The carotenoid content decreased by 11.92%; however, the total chlorophyll content did not change significantly, and the photosynthesis of radish was not affected. In addition, Cs exposure disrupted mineral nutrient homeostasis, decreasing potassium (K), sodium (Na), magnesium (Mg), and iron (Fe) content. The superoxide dismutase (SOD), peroxidase (POD), and catalase (CAT) activities, reactive oxygen species (ROS), and malondialdehyde (MDA) content increased under the different Cs treatments, which indicated that Cs exposure induced oxidative stress response in radish seedlings. Transcriptome analysis detected a total of 4326 differentially expressed genes (DEGs), in which altered expression patterns in genes associated with mineral transport, antioxidant systems, and carotenoid biosynthesis pathways in radish under 2 mM Cs treatment were observed. In conclusion, this study comprehensively investigated the physiological and molecular responses of radish to Cs stress, revealing that Cs accumulation exhibited site-specific preference and concentration dependence and induced physiological disturbances, including growth inhibition and photosynthetic pigment metabolism alterations. At the transcription level, Cs activated the enzymatic antioxidant system, related genes, and stress-response pathways. Notably, this study is the first to demonstrate that Cs disrupts plant mineral nutrition homeostasis and inhibits carotenoid biosynthesis. These findings establish a crucial theoretical foundation for utilizing radish in Cs-contaminated phytoremediation strategies. Full article
(This article belongs to the Special Issue Molecular Mechanisms of Plant Responses to Heavy Metal Stress)
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