Insights into Functional and Medicinal Value of Natural Products from Plants

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Phytochemistry".

Deadline for manuscript submissions: 30 April 2024 | Viewed by 1293

Special Issue Editor


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Guest Editor
Department of Molecular Biosciences, Capio Saint Göran's Hospital, SE-106 91 Stockholm, Sweden
Interests: natural products from plants

Special Issue Information

Dear Colleagues,

Plant-derived natural compounds have long been recognized for their functional and therapeutic benefits. For millennia, they have been utilized in traditional medicine across the world. Plants are essential components in our diet, supplying vitamins, minerals, and other bioactive compounds required for good health and well-being. These products encompass a diverse range of compounds, including alkaloids, flavonoids, terpenoids, phenolic compounds, and many others, which contribute to the rich chemical diversity found in the plant kingdom. In addition to the distinct flavors and smells of these products, they also have antibacterial and antioxidant characteristics that can be used to preserve a wide range of food and beverage products. Furthermore, natural pigments produced by certain plants are utilized in textile coloring. Currently, many pharmacological medications are derived from plants where natural products serve as important starting materials for drug discovery and development. The anti-inflammatory, antimicrobial, antioxidant, anticancer, and immunomodulatory effects are among the most studied biological impacts of natural products, but the potential of natural products in the pharmaceutical and medical fields is unlimited. The current Special Issue aims to provide updated knowledge of the chemical components, the biological functions, the metabolomics profile, and all the other aspects covering the potential of natural products in health care systems.

Prof. Dr. Shaden Khalifa
Guest Editor

Manuscript Submission Information

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Keywords

  • plant-derived natural compounds
  • drug discovery
  • herbal supplement
  • phytochemical profile
  • traditional medicine

Published Papers (1 paper)

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Research

21 pages, 4481 KiB  
Article
Anti-Melanogenic Effects of Lilium lancifolium Root Extract via Downregulation of PKA/CREB and MAPK/CREB Signaling Pathways in B16F10 Cells
by Seokmuk Park, Nayeon Han, Jungmin Lee, Jae-Nam Lee, Sungkwan An and Seunghee Bae
Plants 2023, 12(21), 3666; https://doi.org/10.3390/plants12213666 - 24 Oct 2023
Viewed by 1116
Abstract
Hyperpigmentation disorders causing emotional distress require the topical use of depigmenting agents of natural origin. In this study, the anti-melanogenic effects of the Lilium lancifolium root extract (LRE) were investigated in B16F10 cells. Consequently, a non-cytotoxic concentration of the extract reduced intracellular melanin [...] Read more.
Hyperpigmentation disorders causing emotional distress require the topical use of depigmenting agents of natural origin. In this study, the anti-melanogenic effects of the Lilium lancifolium root extract (LRE) were investigated in B16F10 cells. Consequently, a non-cytotoxic concentration of the extract reduced intracellular melanin content and tyrosinase activity in a dose-dependent manner, correlating with the diminished expression of core melanogenic enzymes within cells. LRE treatment also inhibited cyclic adenosine monophosphate (cAMP) response element-binding protein (CREB)/microphthalmia-associated transcription factor signaling, which regulates the expression of tyrosinase-related genes. Upon examining these findings from a molecular mechanism perspective, LRE treatment suppressed the phosphorylation of protein kinase A (PKA), p38, and extracellular signal-related kinase (ERK), which are upstream regulators of CREB. In addition, L-phenylalanine and regaloside A, specifically identified within the LRE using liquid chromatography-mass spectrometry, exhibited inhibitory effects on melanin production. Collectively, these results imply that LRE potentially suppresses cAMP-mediated melanogenesis by downregulating PKA/CREB and mitogen-activated protein kinase (MAPK)/CREB signaling pathways. Therefore, it can be employed as a novel therapeutic ingredient of natural origin to ameliorate hyperpigmentation disorders. Full article
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