Application of Melatonin to Abiotic Stress in Horticultural Crops

A special issue of Plants (ISSN 2223-7747). This special issue belongs to the section "Plant Response to Abiotic Stress and Climate Change".

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1737

Special Issue Editors


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Guest Editor
College of Horticulture, Hainan University, Haikou 570228, China
Interests: melatonin; antioxidant enzymes; abiotic stress; heavy metals stress; ROS; RNS; plant physiology; plant molecular biology; oxidative stress; ascorbate-glutathione; stress mitigant; plant stress tolerance
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E-Mail Website
Guest Editor
School of Horticulture, Hainan University, Haikou 570228, China
Interests: abiotic stress; plant physiology; salinity; heavy metal; nutrition; micronutrients; antioxidants; phytohormone; heat stress; oxidative stress; reactive oxygen species; reactive nitrogen species; membrane biology; starch physiology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Climate change has become a significant threat to the global production of horticultural crops. To feed the larger part of the world’s growing population, the agricultural output needs to be boosted by 70 percent by the middle of the century, which might supplement about an extra 2.3 billion people. Additionally, horticultural crop production is significantly affected under changing climatic conditions. One of the most critical issues for plant biologists and agronomists is how plants respond to different environmental stimuli. Drought, salt, and high temperatures are the most common environmental stresses that significantly affect plant growth and development. Traditional breeding methods have had little effectiveness due to the complexity of stress tolerance characteristics. They need effective improvements to meet the world’s increasing food demand. It is necessary to develop new and effective methods in this area. Phytohormones might act as a realistic option for producing climate-resistant crops with high yields.

In recent years, melatonin has been identified as a powerful antioxidant molecule. Melatonin has been an alternative eco-friendly approach for increasing abiotic stress tolerance in horticultural crops. Melatonin is a chemical regulator that is released in very small amounts and regulates plant growth, development, and response to the environment in various ways. Melatonin plays an important role during abiotic stress responses in horticultural plants, coordinating differential signal transduction pathways. They are involved in regulating many internal and external stimuli that bring major changes in plant development. Previous literature has revealed that melatonin has been widely studied as a signaling molecule in the response of horticultural crops to abiotic stress. Furthermore, melatonin plays a crucial role in horticultural crop production. Melatonin can regulate the physiological, biochemical, and molecular processes that allow plants to tolerate abiotic stresses, and these methods are becoming more promising in recent times.

This Special Issue aims to shed light on the morphological, physiological, and biochemical processes triggered by the application of melatonin, which ultimately leads to an increase in abiotic stress tolerance in horticultural crops. In this Special Issue, original research articles and reviews are welcome. 

Suggest themes (but not limited to):

  1. The potential role of melatonin in the regulation of abiotic stress in horticultural plants.
  2. The role of ,elatonin mediated cross-talk with other phytohormones in horticultural crops.
  3. Reactive species interaction (reactive oxygen species and reactive nitrogen species) with melatonin in crops under abiotic stress.
  4. The role of melatonin in growth and development of agricultural crops under abiotic stress.
  5. Signaling of melatonin in horticultural crops.
  6. The role of melatonin molecules in heavy metal transport and accumulation.

We look forward to receiving your contributions.

Dr. Muhammad Ahsan Altaf
Prof. Dr. Zhiwei Wang
Guest Editors

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Keywords

  • melatonin
  • abiotic stress
  • antioxidant response
  • oxidative stress
  • plant physiology
  • molecular biology
  • horticultural plants
  • food security
  • tolerance mechanism

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Published Papers (2 papers)

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Research

19 pages, 8378 KiB  
Article
Melatonin Mitigates Cd-Induced Growth Repression and RNA m6A Hypermethylation by Triggering MMR-Mediated DNA Damage Response
by Zihan Tang, Hetong Wang, Xianpeng Wang, Richard A. Ludlow, Zhouli Liu, Min Zhang, Qijiang Cao, Wan Liu and Qiang Zhao
Plants 2025, 14(9), 1398; https://doi.org/10.3390/plants14091398 - 6 May 2025
Viewed by 353
Abstract
Melatonin (MT) has been found to mitigate cadmium (Cd) toxicity with negligible environmental risks. It remains poorly understood as to how MT mitigates Cd-induced growth repression and regulates RNA m6A methylation. We aimed to elucidate the effect of MT on growth [...] Read more.
Melatonin (MT) has been found to mitigate cadmium (Cd) toxicity with negligible environmental risks. It remains poorly understood as to how MT mitigates Cd-induced growth repression and regulates RNA m6A methylation. We aimed to elucidate the effect of MT on growth repression and RNA m6A methylation in Arabidopsis (Arabidopsis thaliana) exposed to Cd stress. MT mitigated, on average, 13.96% and 8.42% of growth repression resulting from Cd and mismatch repair (MMR) deficiency. The ameliorative effect on Cd stress was reduced by 70.56% and 34.23% in msh2 and msh6 mutants, respectively. With distinct dose–effect relationships, m6A hypermethylation responded to Cd stress rather than Cu stress, which was further elevated in MMR-deficient seedlings. MT reduced m6A levels by 22.98% even without stress induction, whereas the depressed m6A levels in MMR-deficient seedlings, greatly exceeding those in the WT. The “writer” and “eraser” gene expression responsible for m6A methylation was reduced with the concentration of stresses due to MT, but VIR and ALKBH9B no longer responded to Cd stress in msh2 and msh6. Despite the remarkable repression, MMR gene expression was regularly promoted by MT under Cd and Cu stress. Our study provides novel insights into the molecular mechanisms underlying the restorative effects of MT on growth repression and m6A methylation regulation, which shed light on Cd phytoremediation. Full article
(This article belongs to the Special Issue Application of Melatonin to Abiotic Stress in Horticultural Crops)
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28 pages, 13072 KiB  
Article
Comparative Physiological and Transcriptomics Profiling Provides Integrated Insight into Melatonin Mediated Salt and Copper Stress Tolerance in Selenicereus undatus L.
by Darya Khan, Xin Yang, Gong He, Raja Asad Ali Khan, Babar Usman, Liu Hui, Aamir Ali Khokhar, Qamar U Zaman and Hua-Feng Wang
Plants 2024, 13(24), 3602; https://doi.org/10.3390/plants13243602 - 23 Dec 2024
Cited by 1 | Viewed by 1084
Abstract
Selenicereus undatus L., (pitaya) is an important tropical fruit crop, and faces significant challenges from soil salinity and heavy metal toxicity. This study explores the role of melatonin (M) in enhancing stress tolerance in pitaya against salinity (S) and copper (Cu) toxicity, both [...] Read more.
Selenicereus undatus L., (pitaya) is an important tropical fruit crop, and faces significant challenges from soil salinity and heavy metal toxicity. This study explores the role of melatonin (M) in enhancing stress tolerance in pitaya against salinity (S) and copper (Cu) toxicity, both individually and in combination (SCu). SCu stress reduced plant biomass by ~54%, while melatonin application mitigated stress effects and increased plant growth by ~73.26% under SCuM compared to SCu treatment. Antioxidant activities were also modulated by stress. Transcriptomic analysis revealed 21 differentially expressed genes (DEGs) common across stress treatments and 13 DEGs specific to combined melatonin with stress treatments involved in stress signaling, secondary metabolite biosynthesis, and photosynthesis. A weighted gene co-expression network analysis (WGCNA) identified four gene modules (brown, dark green, dark grey, and grey) significantly associated with phenotypic traits. A protein–protein interaction (PPI) network analysis highlighted 14 hub genes per module, including GH3, JAZ, PAL, CCR, and POD, implicated in MAPK signaling, phenylpropanoid biosynthesis, and hormone signaling pathways. Integration of DESeq2 and WGCNA identified 12 key stress-responsive genes strongly correlated with phenotypic traits. This study provides insights into regulatory mechanisms underlying stress responses and highlights candidate genes for developing stress-resilient S. undatus through breeding programs. Full article
(This article belongs to the Special Issue Application of Melatonin to Abiotic Stress in Horticultural Crops)
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