Next Article in Journal
Semi-Solid Pharmaceutical Formulations for the Delivery of Papain Nanoparticles
Previous Article in Journal
A Short Review on the Intranasal Delivery of Diazepam for Treating Acute Repetitive Seizures
Previous Article in Special Issue
Development and Evaluation of Feline Tailored Amlodipine Besylate Mini-Tablets Using L-lysine as a Candidate Flavouring Agent
Article

Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs

1
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380494, Chile
2
Advanced Center for Chronic Diseases, Santiago 8380494, Chile
3
Center of New Drugs for Hypertension, Santiago 8380494, Chile
4
Division of Molecular Pharmaceutics and Drug Delivery, College of Pharmacy, University of Texas at Austin, Austin, TX 78712, USA
*
Author to whom correspondence should be addressed.
Pharmaceutics 2020, 12(12), 1168; https://doi.org/10.3390/pharmaceutics12121168
Received: 5 November 2020 / Revised: 19 November 2020 / Accepted: 24 November 2020 / Published: 30 November 2020
(This article belongs to the Special Issue Advances in Oral and Buccal Drug Delivery)
The aim of the study was to develop a novel buccal dosage form to transport rhodamine 123 and human insulin as models for poorly water-soluble and biological drugs, using lipid-core micelles (LCMs)-loaded mucoadhesive films. LCMs were synthesized by a low-energy hot emulsification process, yielding spherically shaped, small-sized, monodispersed and negatively charged carriers with high entrapment efficiency. In vitro release studies demonstrated a higher release of insulin rather than rhodamine from LCMs in simulated physiological conditions, due to an initial burst release effect; however, both release profiles are mainly explained by a diffusion mechanism. Furthermore, LCMs-loaded mucoadhesive films were manufactured and preserved with similar mechanical properties and optimal mucoadhesive behavior compared to nonloaded films. Ex vivo permeation experiments using excised porcine buccal epithelium reveal that both rhodamine and insulin-loaded LCM films elicited a significantly enhanced permeation effect compared to LCMs in suspension and free drugs in solution as controls. Hence, LCMs-loaded mucoadhesive films are suitable as buccal dosage form for the transport and delivery of rhodamine 123 and insulin, as models for poorly water-soluble and biological drugs, respectively. View Full-Text
Keywords: lipid-core micelles; rhodamine 123; poorly water-soluble drugs; human insulin; biological drugs; mechanical properties; mucoadhesive films; buccal administration; in vitro release; ex vivo permeation lipid-core micelles; rhodamine 123; poorly water-soluble drugs; human insulin; biological drugs; mechanical properties; mucoadhesive films; buccal administration; in vitro release; ex vivo permeation
Show Figures

Graphical abstract

MDPI and ACS Style

Chou, W.-H.; Galaz, A.; Jara, M.O.; Gamboa, A.; Morales, J.O. Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs. Pharmaceutics 2020, 12, 1168. https://doi.org/10.3390/pharmaceutics12121168

AMA Style

Chou W-H, Galaz A, Jara MO, Gamboa A, Morales JO. Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs. Pharmaceutics. 2020; 12(12):1168. https://doi.org/10.3390/pharmaceutics12121168

Chicago/Turabian Style

Chou, Wai-Houng, Ariel Galaz, Miguel O. Jara, Alexander Gamboa, and Javier O. Morales 2020. "Drug-Loaded Lipid-Core Micelles in Mucoadhesive Films as a Novel Dosage Form for Buccal Administration of Poorly Water-Soluble and Biological Drugs" Pharmaceutics 12, no. 12: 1168. https://doi.org/10.3390/pharmaceutics12121168

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop