Special Issue "Microneedle Patches: Developing Strategies for Delivery"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (31 August 2015).
Microneedle technology for drug delivery has grown significantly in the last 15 years. Microneedles have been shown to be able to deliver a range of drugs, vaccines, and genes, e.g., large molecular weight drugs that are larger than 500 Da. Microneedles are very versatile in delivering either solid or liquid drug formulations. Furthermore, it has been shown that microneedle technology can be combined with other methods, such as ultrasound and iontophoresis. Microneedles have been manufactured from a wide range of materials, such as polymers (e.g., polycarbonates and silk fibroin) and metals (e.g., titanium and stainless steel). Novel techniques of production have also been introduced in the past few decades, which include spatially discrete thermal drawing, centrifuge molding, and laser drilling. Microneedles have a promising prospect to transform drug and vaccine delivery, with the potential to improve mass vaccination programs, and facilitate more controlled drug delivery to delicate areas, such as the eye and neurons, thus eliminating the pain, discomfort, and risks associated with drug delivery via hypodermic needles. In particular, there is a significant amount of interest in the area of insulin delivery, where use of microneedles results in a drug release profile, which better mimics the natural insulin release in the body. The prospect of dose sparing and improved stability of vaccines in the dry form has raised a lot of research interest in vaccine delivery via microneedles. Thus, microneedle technology is an increasingly broad area of research interest. Keeping these facts in mind, the journal Special Issue invites papers on the following areas:
(i) Materials for microneedle systems
(ii) Manufacture of microneedle systems
(iii)Combination of microneedles with other methods
(iv) Pre-clinical and clinical studies using microneedle systems
(v) Modeling and optimization of microneedle systems
(vi) Permeation studies involving microneedle pierced skin.
Dr. Diganta B Das
Dr. Ololade Olatunji
Manuscript Submission Information
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- permeation study
- modeling and optimization
- materials for microneedles
- manufacturing method