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Microneedle Coating Techniques for Transdermal Drug Delivery

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School of Pharmacy, De Montfort University, Leicester LE1 9BH, UK
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Department of Pharmacy, Bahauddin Zakariya University, Multan 60800, Pakistan
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College of Pharmacy, University of the Punjab, Lahore 54000, Pakistan
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State Key Laboratory of Silicon Materials, School of Materials Science and Engineering, Zhejiang University, Hangzhou 310027, China
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College of Biomedical Engineering and Instrument Science, Zhejiang University, Hangzhou 310027, China
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Zhejiang Provincial Key Laboratory of Cardio-Cerebral Vascular Detection Technology and Medicinal Effectiveness Appraisal, Zhejiang University, Hangzhou 310027, China
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Authors to whom correspondence should be addressed.
Academic Editor: Diganta B. Das
Pharmaceutics 2015, 7(4), 486-502; https://doi.org/10.3390/pharmaceutics7040486
Received: 21 September 2015 / Revised: 28 October 2015 / Accepted: 28 October 2015 / Published: 5 November 2015
(This article belongs to the Special Issue Microneedle Patches: Developing Strategies for Delivery)
Drug administration via the transdermal route is an evolving field that provides an alternative to oral and parenteral routes of therapy. Several microneedle (MN) based approaches have been developed. Among these, coated MNs (typically where drug is deposited on MN tips) are a minimally invasive method to deliver drugs and vaccines through the skin. In this review, we describe several processes to coat MNs. These include dip coating, gas jet drying, spray coating, electrohydrodynamic atomisation (EHDA) based processes and piezoelectric inkjet printing. Examples of process mechanisms, conditions and tested formulations are provided. As these processes are independent techniques, modifications to facilitate MN coatings are elucidated. In summary, the outcomes and potential value for each technique provides opportunities to overcome formulation or dosage form limitations. While there are significant developments in solid degradable MNs, coated MNs (through the various techniques described) have potential to be utilized in personalized drug delivery via controlled deposition onto MN templates. View Full-Text
Keywords: microneedles; coatings; drug delivery; coating process; films; particles microneedles; coatings; drug delivery; coating process; films; particles
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Haj-Ahmad, R.; Khan, H.; Arshad, M.S.; Rasekh, M.; Hussain, A.; Walsh, S.; Li, X.; Chang, M.-W.; Ahmad, Z. Microneedle Coating Techniques for Transdermal Drug Delivery. Pharmaceutics 2015, 7, 486-502.

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