Metallodrugs for Targeted Cancer Therapy
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Targeting and Design".
Deadline for manuscript submissions: closed (1 February 2022) | Viewed by 21886
Special Issue Editors
Interests: bioinorganic chemistry; gold; silver; copper; PTA; colon cancer; metallodrugs
Interests: d6-metal complexes; gold chemistry; lanthanides; luminescence; bioactivity; antitumorals; cytotoxicity; bioimaging
Special Issue Information
Dear Colleagues,
DNA is considered as the primary target of platinum-based drugs, however, this DNA binding mechanism may damage normal cells and cause serious side effects. Recent research in the field of genomic and proteomics has identified different proteins or enzymes able to maintain the survival or progression of cancer cells. Most of these proteins are overexpressed in human tumors. Consequently, the design of anticancer agents able to target these proteins has become as an ideal approach for cancer treatment.
Many cancer-related proteins associated with the antimetastatic, antiangiogenic and antiproliferative activity have been identified as molecular targets for different metal complexes. Thus, metal complexes containing, e.g., ruthenium, osmium, rhodium, iridium, gold, copper, tin among others, could be turned out to be promising candidates in anticancer therapy, in addition to the platinum derivatives.
Metal complexes can easily modify ligands, oxidation states and coordination number in order to improve their biological activities. In addition, the excellent optical properties of luminescent metal complexes, such as long-lived phosphorescence, high photo stability and large Stokes shifts, allows their use as both imaging and therapeutic agents.
This Special Issue of Pharmaceutics, entitled “Metallodrugs for Targeted Cancer Therapy” welcomes original research focusing on the aspects of design, characterization, evaluation, development of metal complexes able to interact with biological targets, drug delivery and bioimaging in order to get cancer diagnoses and treatments.
Dr. Elena Cerrada
Dr. Vanesa Fernández-Moreira
Guest Editors
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Keywords
- drug-design
- mechanisms of cell death
- drug uptake
- structure-activity-relationships
- toxicity
- pharmacokinetics
- metabolism
- cancer treatment
- clinical trials
- metal-based drug delivery agents
- metal-protein interactions
- metal-nucleic acid interactions
- phototherapic and photodiagnostic materials
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