Special Issue "Micro/Nano-Bubbles as a New Ultrasound Imaging and Drug Delivery Tool"
A special issue of Pharmaceutics (ISSN 1999-4923).
Deadline for manuscript submissions: closed (15 April 2019).
Dear Colleagues,Recently, various types of microbubbles ("fine bubbles" larger than 1 µm) and smaller nanobubbles ("ultrafine bubbles" less than 1 µm diameter) for ultrasound contrast imaging have been under development. The advantage of small bubbles is their capability to easily perfuse into the capillaries, resulting in detailed images of biological tissues, such as tumors and normal organs. These bubbles can become a superior ultrasound contrast agent compared to larger bubbles. Other than their size, shelled and non-shelled bubbles have shown different acoustic characters, ultrasound images, and biological reactions. Utilizing bubble-shell material may permit molecular targeting and imaging. Another exciting aspect of bubbles is their ability to carry and delivery drugs to a specific location within the body. The collapse of bubbles due to high intensity-focused ultrasound in a localized area can induce or boost the sonoporation phenomenon, resulting in the opening of a hard-to-penetrate blood–brain barrier or increasing cell membrane permeability. Although the mechanism of sonoporation and imaging of nanobubbles are not known, combining ultrasound and bubbles may prove to be an ideal, non-invasive therapy/diagnosis (theranositcs) modality. This Special Issue invites manuscripts on subjects relating to ultrasound imaging and drug-delivery systems by means of micro and nano-bubbles.
Prof. Katsuro Tachibana
Manuscript Submission Information
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- ultrasound contrast agent
- molecular targeting and imaging
- drug delivery system
- high-intensity-focused ultrasound
- sonodynamic therapy
- gene therapy