15th Anniversary of Pharmaceutics—Improvement of Drug Bioavailability

Dear Colleagues,

Improving the bioavailability of drugs is a critical aspect of pharmaceutical development, as it can lead to better therapeutic outcomes and reduced dosages, thereby minimizing side effects. Bioavailability refers to the proportion of the administered dose of a drug that reaches the systemic circulation and is available to exert its pharmacological effects. This Anniversary Special Issue for the topic “Improvement of bioavailability” will collect some strategies that pharmaceutical researchers and scientists employ to enhance the bioavailability of drugs: formulation optimization, prodrug design, nanotechnology, use of excipients, amorphous solid dispersions, pH adjustment, salt formation, particle size reduction, enhanced permeability, inclusion complexes, co-crystals, modified release formulations, targeted drug delivery.

Due to their inherent and unique physico-chemical characteristics (crystallinity, solubility, stability), each drug, and the appropriate strategy to improve its bioavailability, will depend on its specific characteristics and challenges, such as the administration route. Indeed, pharmaceutical scientists often conduct thorough studies and optimization to select the most effective approach for each particular drug. These strategies will also consider the poor water-soluble characteristics of the drugs to enable adequate bioavailability after administration. This solubility problem greatly hinders pharmaceutical development and ultimately prevents patients from accessing potentially life-saving treatments.

I look forward to receiving your contributions.

Prof. Dr. Thierry Vandamme
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.