Advanced Research on Amorphous Drugs
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: 31 August 2025 | Viewed by 79
Special Issue Editor
Interests: poorly water-soluble drugs; crystalline/amorphous drugs; amorphous solid dispersions; nanocrystals; novel drug-delivery systems
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
With advancements in high-throughput screening and combinatorial chemistry, the efficiency of new drug development has markedly increased. However, many new drugs still face significant challenges due to poor water solubility, which limits their bioavailability. Amorphous drug formulations have emerged as a promising solution to this problem, offering enhanced solubility by increasing the free energy of poorly water-soluble compounds. However, this increase in free energy also elevates the risk of physical instability, which presents a major challenge in developing stable and effective amorphous formulations.
This Special Issue will feature original research and comprehensive review articles, aiming to explore the latest advancements in the development of amorphous drug formulations. Topics of interest include, but are not limited to, innovative preparation methods, novel evaluation techniques, advanced predictive models for physical stability, and mechanistic insights into the behavior of amorphous drug formulations. Experts in these fields are invited to contribute their work to this Special Issue.
Prof. Dr. Qiang Fu
Guest Editor
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Keywords
- high-throughput screening
- combinatorial chemistry
- poorly water-soluble compounds
- poor water solubility
- bioavailability
- innovative preparation methods
- amorphous drug formulations
- free energy
- novel evaluation techniques
- advanced predictive models
- physical stability
- mechanistic insights
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