Formulation of Poorly Water-Soluble Drugs
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".
Deadline for manuscript submissions: closed (30 June 2024) | Viewed by 8029
Special Issue Editors
Interests: poorly water-soluble drugs; crystalline/amorphous drugs; amorphous solid dispersions; nanocrystals; novel drug-delivery systems
Interests: lipid nanoparticles; zwitterionic micelles; drug conjugates; nanosuspensions
Special Issue Information
Dear Colleagues,
In recent years, the emergence of poorly water-soluble drug candidates in the drug development pipeline has been a challenging issue for the pharmaceutical industry. Increasing the bioavailability of these drugs via the improvement of solubility/dissolution has become a major concern in the efforts to develop a reasonable dosing regimen for patients. Many delivery systems, such as cocrystals, nanocrystals, nanoparticles, inclusion complex, amorphous solid dispersions, and lipid-based formulations have been developed to overcome these problems. The use of novel methods not only increases the solubility and permeability of the poorly bioavailable drugs but also improves their stability and targeting efficacy. Moreover, in order to select the best approach some critical considerations must be taken into account, for example the physicochemical properties of the drug, the possibility to scale-up the production process, the toxicological considerations of the use of adjuvant, and the development of a more patient-friendly dosage form.
This Special Issue aims to collect groundbreaking studies and valuable reviews on the formulation of poorly water-soluble drugs.
Prof. Dr. Qiang Fu
Dr. Xiangfei Han
Dr. Longfa Kou
Guest Editors
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Keywords
- poorly water-soluble drugs
- solubility
- dissolution enhancement
- oral bioavailability
- physico-chemical properties
- drug delivery
- formulation design
- cocrystals
- nanocrystals
- inclusion complex
- amorphous solid dispersions
- nanoparticles
- liposome
- lipid-based formulations
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