Drug Delivery and Pharmacokinetics in Oral Medicine and Dental Infection, 2nd Edition

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (20 May 2025) | Viewed by 436

Special Issue Editors


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Guest Editor
1. Houston Methodist Research Institute, Houston, TX, USA
2. Bioengineering R&D Center Kragujevac, Kragujevac, Serbia
3. Serbian Academy of Science and Arts, Belgrade, Serbia
Interests: drug delivery; computational models; physiological barriers; drug vectors; implant devices; imaging analysis; immunotherapy; microenvironment; intra-tumoral pharmacokinetics
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Special Issue Information

Dear Colleagues,

The most prevalent dental infections are dental caries and periodontal, endodontic, and implant-related infections. They are mainly of polymicrobial origin and caused by various combinations of viruses, bacteria, and fungi. Many of these infections occur as biofilms that act as a barrier to antimicrobial agents, presenting a treatment challenge.

The oral cavity and dental tissues present a unique and challenging environment that may impair the penetration and effect of antimicrobial substances, limiting their therapeutic potential. Thus, effective drug delivery and understanding their pharmacokinetics are paramount.

We invite authors to submit original research and review articles on contemporary conventional and nanotechnology-based innovative drug delivery systems that will help us reach a better understanding of the management of dental infections.

Dr. Igor Tsesis
Prof. Dr. Milos Kojic
Guest Editors

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Keywords

  • oral drug delivery
  • dental infection/pain
  • oral medicine
  • drug delivery
  • pharmacokinetics
  • controlled release
  • periodontal and endodontic infections

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Published Papers (1 paper)

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Review

28 pages, 1100 KiB  
Review
Application of Gene Therapy to Oral Diseases
by Seiichi Yamano, Kenji Inoue and Yoichiro Taguchi
Pharmaceutics 2025, 17(7), 859; https://doi.org/10.3390/pharmaceutics17070859 - 30 Jun 2025
Viewed by 211
Abstract
Gene therapy has emerged as a promising therapeutic approach across various oral diseases. This review examines current applications and future prospects of gene therapy in dentistry, focusing on five key areas: oral cancer, cancer-related pain, xerostomia (dry mouth), dental caries, and periodontal disease. [...] Read more.
Gene therapy has emerged as a promising therapeutic approach across various oral diseases. This review examines current applications and future prospects of gene therapy in dentistry, focusing on five key areas: oral cancer, cancer-related pain, xerostomia (dry mouth), dental caries, and periodontal disease. Recent advances in viral and non-viral vectors have enabled more efficient gene delivery systems, with particular success in cancer pain management through µ-opioid receptor gene transfer and xerostomia treatment using aquaporin-1 gene therapy. For periodontal applications, gene therapy strategies include both immunomodulation and tissue regeneration approaches using growth factors like platelet-derived growth factor and bone morphogenetic proteins. While significant progress has been made, particularly in treating radiation-induced xerostomia and oral cancer pain, challenges remain in vector optimization and delivery methods. Clinical trials, predominantly in Phase I, indicate both the potential and current limitations of gene therapy in oral healthcare. This review synthesizes current evidence and outlines future directions for gene therapy applications in oral medicine and dentistry. Full article
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