Oral and Maxillofacial Surgery: Balance Between Innovative and Proven Procedures, Drugs and Materials, 2nd Edition

A special issue of Surgeries (ISSN 2673-4095).

Deadline for manuscript submissions: 20 November 2025 | Viewed by 876

Special Issue Editor

Special Issue Information

Dear Colleagues,

The clash between experience and modernity is a particularly delicate issue in medicine. Effective and safe treatments always encompass a balance between the old and the new. The choice between that which has been repeatedly confirmed and what is potentially better, although burdened with a higher risk, affects the course of diagnostic and therapeutic processes. Additional factors in the degree of the difficulty of procedures, the availability of medical equipment, and the cost-effectiveness further complicate the choices that, in theory, should be dictated solely by medical considerations. I consider these topics worth covering in this Special Issue, which I invite you to cocreate, with the aim of presenting the best proven practices, innovative clinical management, and prospects for the development of oral and maxillofacial surgery.

Potential topics include, but are not limited to, the following:
best proven vs. the latest diagnostic methods; advances in craniofacial traumatology; predictable orthognathics in the context of digitization; innovations in the treatment of temporomandibular joints; apparent stagnation in inflammation therapy; constant and developing aspects of oncology; novelties vs. traditional methods in reconstructive surgery; dental implantology: the evidence-based race of innovation; postsurgical maxillofacial prosthetics; importance and new possibilities of postoperative observation; failures necessary to share to avoid their occurrence.

Dr. Igor Tsesis
Guest Editor

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Keywords

  • diagnostic techniques and procedures
  • maxillofacial injuries
  • orthognathic surgery
  • temporomandibular joint disorders
  • oral and maxillofacial pathology
  • reconstructive surgery
  • iatrogenic disease

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Published Papers (1 paper)

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20 pages, 1220 KiB  
Systematic Review
The Evolving Role of Stem Cells in Oral Health and Regeneration: A Systematic Review
by Gianna Dipalma, Grazia Marinelli, Arianna Fiore, Liviana Balestriere, Claudio Carone, Silvio Buongiorno, Francesco Inchingolo, Giuseppe Minervini, Andrea Palermo, Angelo Michele Inchingolo and Alessio Danilo Inchingolo
Surgeries 2025, 6(3), 65; https://doi.org/10.3390/surgeries6030065 - 30 Jul 2025
Viewed by 598
Abstract
Background: Mesenchymal stem cells (MSCs), multipotent and immune-regulatory cells derived from tissues such as bone marrow, dental pulp, and periodontal ligament, emerged as promising agents in regenerative dentistry. Their clinical applications include endodontic tissue regeneration, periodontal healing, and alveolar bone repair, addressing [...] Read more.
Background: Mesenchymal stem cells (MSCs), multipotent and immune-regulatory cells derived from tissues such as bone marrow, dental pulp, and periodontal ligament, emerged as promising agents in regenerative dentistry. Their clinical applications include endodontic tissue regeneration, periodontal healing, and alveolar bone repair, addressing critical challenges in dental tissue restoration. Methods: A systematic review was conducted following PRISMA guidelines and registered in PROSPERO. We searched PubMed, Scopus, and Web of Science databases for open-access, English-language clinical trials and observational studies published from 2015 to 2025. Studies focusing on the application of MSCs in dental tissue regeneration were included based on predefined eligibility criteria. Results: Out of 2400 initial records, 13 studies met the inclusion criteria after screening and eligibility assessment. Most studies investigated MSCs derived from dental pulp and periodontal ligament for regenerating periodontal tissues and alveolar bone defects. The majority reported improved clinical outcomes; however, variations in MSC sources, delivery methods, sample sizes, and follow-up periods introduced methodological heterogeneity. Conclusions: MSCs show significant potential in enhancing bone and periodontal regeneration in dental practice. Nonetheless, the current evidence is limited by small sample sizes, short follow-up, and inconsistent methodologies. Future large-scale, standardized clinical trials are required to validate MSC-based regenerative therapies and optimize treatment protocols. Full article
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