Functional Bionanomaterials: Perspectives in Respiratory Disease Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 654

Special Issue Editor


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Guest Editor
Departamento de Física, Universidad de Sonora, Hermosillo 83000, Mexico
Interests: nanotechnology applications in biomedicine fields; development of biomaterials; physicochemical properties of biomacromolecules; protein aggregation; biomolecules adsorption at interfaces
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Special Issue Information

Dear Colleagues,

Nanotechnology has emerged as a pivotal tool for designing and creating functional biomaterials with unique characteristics tailored to meet specific needs across various fields of science and technology. In particular, functional bionanomaterials in biomedicine offer a wide range of applications in medicine, including cancer treatment, tissue regeneration, respiratory diseases, and so forth. Bionanomaterials can be constructed using organic components (lipids, natural, and synthetic polymers), inorganic materials (metals, metallic oxides, and metals alloys), or a combination of both. These materials are designed to load, transport, and deliver bioactive compounds—such as drugs, proteins, and peptides, among others—to target specific diseases effectively. This Special Issue aims to gather original and innovative reviews, as well as research articles, focused on the development of functional bionanomaterials with potential applications in the treatment of respiratory diseases. The objective is to provide the scientific community and interested readers with cutting-edge insights into functional bionanomaterials and their promising applications in the treatment of respiratory disease.

I look forward to receiving your contributions.

Dr. Josué Juárez
Guest Editor

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Keywords

  • nanotechnology
  • bionanomaterials
  • biomedicine
  • respiratory diseases
  • microorganisms
  • 2D and 3D biomaterials
  • polymeric nanoparticles
  • inorganic nanoparticles
  • hybrid nanoparticles

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Published Papers (1 paper)

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Research

24 pages, 2554 KiB  
Article
Phytosynthesis and Characterization of Silver Nanoparticles from Antigonon leptopus: Assessment of Antibacterial and Cytotoxic Properties
by Marisol Gastelum-Cabrera, Pablo Mendez-Pfeiffer, Manuel G. Ballesteros-Monrreal, Brenda Velasco-Rodríguez, Patricia D. Martínez-Flores, Sergio Silva-Bea, Vicente Domínguez-Arca, Gerardo Prieto, Silvia Barbosa, Ana Otero, Pablo Taboada and Josué Juárez
Pharmaceutics 2025, 17(5), 672; https://doi.org/10.3390/pharmaceutics17050672 - 20 May 2025
Viewed by 455
Abstract
Background: Silver nanoparticles (AgNPs) show promises as antimicrobial biomaterials with use for combating multidrug-resistant microorganisms, and they are widely used in healthcare, medicine, and food industries. However, traditional physicochemical synthesis methods often require harsh conditions and toxic reagents, generating harmful waste. The synthesis [...] Read more.
Background: Silver nanoparticles (AgNPs) show promises as antimicrobial biomaterials with use for combating multidrug-resistant microorganisms, and they are widely used in healthcare, medicine, and food industries. However, traditional physicochemical synthesis methods often require harsh conditions and toxic reagents, generating harmful waste. The synthesis of AgNPs using plant-derived bioactive compounds offers an eco-friendly alternative to conventional methods. Methods: In this study, a bio-green approach was employed to synthesize AgNPs using ethanolic extracts from Antigonon leptopus leaves (EXT-AL). The synthesis was optimized under different pH conditions (5.5, 8.0, 10.0) and EXT-AL concentrations (10–200 μg/mL). Antibacterial activity was evaluated against Escherichia coli and Staphylococcus aureus, and cytotoxicity was assessed in HeLa, CaCo-2, T731-GFP, and HaCaT cell lines. Results: UV-Vis spectroscopy confirmed nanoparticle formation, with a surface plasmon resonance peak at 410 nm. Alkaline conditions (pH 10.0) favored the formation of smaller, spherical AgNPs. Characterization by DLS, TEM, and AFM revealed uniform nanoparticles with a hydrodynamic diameter of 93.48 ± 1.88 nm and a zeta potential of −37.80 ± 1.28 mV. The AgNPs remained stable in Milli-Q water but tended to aggregate in PBS, DMEM, and MHB media. Antibacterial assays demonstrated significant bactericidal activity against Escherichia coli and Staphylococcus aureus at 3.9 μg/mL (Ag⁺ equivalent). Cytotoxicity tests showed no toxicity to HeLa, T731-GFP, CaCo-2, or HaCaT cells at concentrations ≥ 7.8 μg/mL after 24 h. Conclusions: These findings highlight Antigonon leptopus extract as a sustainable and cost-effective resource for AgNPs synthesis, with strong antimicrobial properties and potential biomedical applications. Full article
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