Host–Microbe Interactions in Health and Disease

A special issue of Microbiology Research (ISSN 2036-7481).

Deadline for manuscript submissions: 31 October 2025 | Viewed by 786

Special Issue Editors


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Guest Editor
Departamento de Física, Universidad de Sonora, Hermosillo 83000, Mexico
Interests: nanotechnology applications in biomedicine fields; development of biomaterials; physicochemical properties of biomacromolecules; protein aggregation; biomolecules adsorption at interfaces
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Guest Editor Assistant
Departamento de Ciencias Químico Biológicas y Agropecuarias, Universidad de Sonora, Caborca CP 83600, Mexico
Interests: bacteria; antimicrobial therapy; nanotechnology; drug delivery systems; host-microbe interactions

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Guest Editor Assistant
Departamento de Ciencias Químico Biológicas y Agropecuarias, Universidad de Sonora, Caborca CP 83600, Mexico
Interests: Escherichia coli; epidemiology; host-microbe interactions; antibacterial therapy

Special Issue Information

Dear Colleagues,

Understanding the complex interplay between hosts and microbes is essential for unraveling the mechanisms underlying health and disease. This Special Issue explores the multifaceted interactions between the human host and its resident or invading microbial communities, including bacteria, viruses, fungi, and parasites. From mutualistic relationships that support immune development and metabolic balance to pathogenic interactions driving chronic inflammation, infection, and systemic disease, this collection highlights recent advances in microbiology, immunology, and systems biology.

Contributions cover diverse topics such as the role of the microbiota in modulating immune responses, mechanisms of microbial pathogenesis, host genetic and epigenetic factors influencing susceptibility to infection, and emerging insights into microbial dysbiosis in diseases such as cancer, metabolic syndrome, and autoimmune disorders. This Special Issue also addresses novel therapeutic strategies, including microbiome-targeted interventions, probiotics, phage therapy, and antimicrobial resistance management.

By integrating basic and translational research, this Special Issue aims to provide a comprehensive perspective on how host–microbe interactions shape health outcomes. It is intended for researchers, clinicians, and public health experts interested in the latest developments in microbial ecology, infection biology, and personalized medicine approaches for disease prevention and treatment.

Dr. Josué Juárez
Guest Editor

Dr. Pablo Mendez-Pfeiffer
Dr. Manuel Ballesteros-Monrreal
Guest Editor Assistants

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Keywords

  • host–microbe interactions
  • microbiota
  • microbial pathogenesis
  • immune response
  • antimicrobial resistance
  • gut microbiome
  • host response
  • dysbiosis
  • antimicrobial therapy

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Published Papers (1 paper)

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Research

13 pages, 892 KiB  
Article
Comparative Evaluation of Recombinant Chlamydia abortus and Chlamydia trachomatis Major Outer Membrane Proteins for Diagnosing Human Chlamydial Infection
by Fernando M. Guerra-Infante, María J. de Haro-Cruz, Marcela López-Hurtado, Miguel A. De la Rosa-Ramos, Efrén Díaz-Aparicio and Beatriz Arellano-Reynoso
Microbiol. Res. 2025, 16(7), 159; https://doi.org/10.3390/microbiolres16070159 - 9 Jul 2025
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Abstract
Chlamydia trachomatis infection is a public health problem. Serological tests can determine the disease burden and serve as a biomarker for identifying patients with infertility due to tubal obstruction. However, cross-reactions between chlamydial species have been reported, which causes problems with diagnosis. A [...] Read more.
Chlamydia trachomatis infection is a public health problem. Serological tests can determine the disease burden and serve as a biomarker for identifying patients with infertility due to tubal obstruction. However, cross-reactions between chlamydial species have been reported, which causes problems with diagnosis. A real-time PCR commercial test for the detection of endocervical infection and two ELISAs with the recombinant major outer membrane protein (rMOMP) from C. trachomatis and C. abortus as antigens were used to diagnose both infections. The prevalence of endocervical infection by C. trachomatis was 7.77%, and that of IgG antibodies against C. trachomatis and C. abortus was 31.1% and 10.7%, respectively. The ELISA with C. trachomatis rMOMP showed a sensitivity of 75% and a specificity of 72.5%. The lowest sensitivity (25%) and high specificity (76.8%) were obtained with anti-C. abortus rMOMP ELISAs. A low cross-reactivity of 7% between ELISA tests was observed. Conclusion. The recombinant MOMP ELISA could help identify women who had contact with C. trachomatis or C. abortus and could be a tool to lower the costs of performing molecular testing on all patients attending an infertility clinic. Full article
(This article belongs to the Special Issue Host–Microbe Interactions in Health and Disease)
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