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Microbiology Research
Special Issues
Host–Microbe Interactions in Health and Disease
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Host–Microbe Interactions in Health and Disease

A special issue of Microbiology Research (ISSN 2036-7481).

Deadline for manuscript submissions: 31 October 2025 | Viewed by 1117

Special Issue Editors

Dr. Josué Juárez

E-Mail Website
Guest Editor
Departamento de Física, Universidad de Sonora, Hermosillo 83000, Mexico
Interests: nanotechnology applications in biomedicine fields; development of biomaterials; physicochemical properties of biomacromolecules; protein aggregation; biomolecules adsorption at interfaces
Special Issues, Collections and Topics in MDPI journals
Dr. Pablo Mendez-Pfeiffer

E-Mail Website
Guest Editor Assistant
Departamento de Ciencias Químico Biológicas y Agropecuarias, Universidad de Sonora, Caborca CP 83600, Mexico
Interests: bacteria; antimicrobial therapy; nanotechnology; drug delivery systems; host-microbe interactions
Dr. Manuel Ballesteros-Monrreal

E-Mail
Guest Editor Assistant
Departamento de Ciencias Químico Biológicas y Agropecuarias, Universidad de Sonora, Caborca CP 83600, Mexico
Interests: Escherichia coli; epidemiology; host-microbe interactions; antibacterial therapy

Special Issue Information

Dear Colleagues,

Understanding the complex interplay between hosts and microbes is essential for unraveling the mechanisms underlying health and disease. This Special Issue explores the multifaceted interactions between the human host and its resident or invading microbial communities, including bacteria, viruses, fungi, and parasites. From mutualistic relationships that support immune development and metabolic balance to pathogenic interactions driving chronic inflammation, infection, and systemic disease, this collection highlights recent advances in microbiology, immunology, and systems biology.

Contributions cover diverse topics such as the role of the microbiota in modulating immune responses, mechanisms of microbial pathogenesis, host genetic and epigenetic factors influencing susceptibility to infection, and emerging insights into microbial dysbiosis in diseases such as cancer, metabolic syndrome, and autoimmune disorders. This Special Issue also addresses novel therapeutic strategies, including microbiome-targeted interventions, probiotics, phage therapy, and antimicrobial resistance management.

By integrating basic and translational research, this Special Issue aims to provide a comprehensive perspective on how host–microbe interactions shape health outcomes. It is intended for researchers, clinicians, and public health experts interested in the latest developments in microbial ecology, infection biology, and personalized medicine approaches for disease prevention and treatment.

Dr. Josué Juárez
Guest Editor

Dr. Pablo Mendez-Pfeiffer
Dr. Manuel Ballesteros-Monrreal
Guest Editor Assistants

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Microbiology Research is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1600 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • host–microbe interactions
  • microbiota
  • microbial pathogenesis
  • immune response
  • antimicrobial resistance
  • gut microbiome
  • host response
  • dysbiosis
  • antimicrobial therapy

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Further information on MDPI's Special Issue policies can be found here.

Published Papers (3 papers)

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Research

23 pages, 5810 KiB  
Article
Oral Intake of Klebsiella oxytoca Disrupts Murine Intestinal Bacteriota and Anti-K. oxytoca Compound Baicalin by In Silico and In Vitro Analysis
by Yuming Ma, Xinchi Qin, Yongjie Wang, Lu Xie and Lanming Chen
Microbiol. Res. 2025, 16(8), 189; https://doi.org/10.3390/microbiolres16080189 - 14 Aug 2025
Abstract
Klebsiella oxytoca originating from shellfish Scapharca subcrenata contains a number of virulence-related genes. In this study, we investigated its pathogenicity using a murine intestinal infection model and predicted its antibacterial compounds and targets via molecular docking analysis. The results revealed that the intake [...] Read more.
Klebsiella oxytoca originating from shellfish Scapharca subcrenata contains a number of virulence-related genes. In this study, we investigated its pathogenicity using a murine intestinal infection model and predicted its antibacterial compounds and targets via molecular docking analysis. The results revealed that the intake of K. oxytoca 8-2-11 strain (109 CFU/day) via oral gavage for 7 days reduced the average body weight of the mice. The bacterium was present in fecal samples but absent from blood, lung, and liver samples from the mice. The intake of K. oxytoca 8-2-11 significantly altered colon bacteriota, with reduced abundance of Firmicutes, Lachnospiraceae, Lactobacillaceae, Lactobacillus, and Lactobacillus murinus, and increased in Bacteroidota, Muribaculaceae, and Alistipes (p < 0.05). Forty-four bioactive compounds in Scutellaria baicalensis and Forsythia suspensa were screened for docking with 117 potential virulence factors (VFs) in K. oxytoca 8-2-11. The compound baicalin displayed higher binding affinity toward these VFs, with the lowest mean binding energy (−8.4 kcal/mol). Baicalin was able to bind to key VFs in biofilm formation and adherence/motility (e.g., Mrks and EcpA) via forming stable hydrogen bonds, π-stacking, and π-cation interaction. In vitro, baicalin inhibited the bacterial growth and biofilm formation. This study establishes the first murine infection model using aquatic animal-derived K. oxytoca, and it provides candidate antibacterial compounds and targets for control of K. oxytoca infections. Full article
(This article belongs to the Special Issue Host–Microbe Interactions in Health and Disease)
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13 pages, 1098 KiB  
Article
Risk Factors and Seroprevalence of Infection by Corynebacterium pseudotuberculosis in Goats from Espírito Santo State, Southeastern Brazil
by Letícia Pereira Pedrini Vicentini, Thiago Doria Barral, Marcus Alexandre Vaillant Beltrame, Luiz Filippe Simão Soares, Ricardo Wagner Portela and Blima Fux
Microbiol. Res. 2025, 16(8), 185; https://doi.org/10.3390/microbiolres16080185 - 8 Aug 2025
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Abstract
Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis, a significant infectious disease that affects small ruminants and poses economic challenges to livestock production. This study aimed to assess the seroprevalence of C. pseudotuberculosis in goats from Espírito Santo state, Brazil, and identify [...] Read more.
Corynebacterium pseudotuberculosis is the causative agent of caseous lymphadenitis, a significant infectious disease that affects small ruminants and poses economic challenges to livestock production. This study aimed to assess the seroprevalence of C. pseudotuberculosis in goats from Espírito Santo state, Brazil, and identify risk factors associated with infection by the bacterium. Serum samples from 145 goats were analyzed using an indirect enzyme-linked immunosorbent assay (ELISA). The overall seroprevalence was found to be 34.5%. The risk factors significantly associated with infection included the presence of abscesses and the absence of veterinary assistance on farms. The findings emphasize the need for improved management practices and veterinary oversight to mitigate caseous lymphadenitis transmission. This research provides critical insights into the epidemiology of caseous lymphadenitis in goats from Espírito Santo, informing effective disease control strategies. Full article
(This article belongs to the Special Issue Host–Microbe Interactions in Health and Disease)
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Figure 1

13 pages, 892 KiB  
Article
Comparative Evaluation of Recombinant Chlamydia abortus and Chlamydia trachomatis Major Outer Membrane Proteins for Diagnosing Human Chlamydial Infection
by Fernando M. Guerra-Infante, María J. de Haro-Cruz, Marcela López-Hurtado, Miguel A. De la Rosa-Ramos, Efrén Díaz-Aparicio and Beatriz Arellano-Reynoso
Microbiol. Res. 2025, 16(7), 159; https://doi.org/10.3390/microbiolres16070159 - 9 Jul 2025
Viewed by 338
Abstract
Chlamydia trachomatis infection is a public health problem. Serological tests can determine the disease burden and serve as a biomarker for identifying patients with infertility due to tubal obstruction. However, cross-reactions between chlamydial species have been reported, which causes problems with diagnosis. A [...] Read more.
Chlamydia trachomatis infection is a public health problem. Serological tests can determine the disease burden and serve as a biomarker for identifying patients with infertility due to tubal obstruction. However, cross-reactions between chlamydial species have been reported, which causes problems with diagnosis. A real-time PCR commercial test for the detection of endocervical infection and two ELISAs with the recombinant major outer membrane protein (rMOMP) from C. trachomatis and C. abortus as antigens were used to diagnose both infections. The prevalence of endocervical infection by C. trachomatis was 7.77%, and that of IgG antibodies against C. trachomatis and C. abortus was 31.1% and 10.7%, respectively. The ELISA with C. trachomatis rMOMP showed a sensitivity of 75% and a specificity of 72.5%. The lowest sensitivity (25%) and high specificity (76.8%) were obtained with anti-C. abortus rMOMP ELISAs. A low cross-reactivity of 7% between ELISA tests was observed. Conclusion. The recombinant MOMP ELISA could help identify women who had contact with C. trachomatis or C. abortus and could be a tool to lower the costs of performing molecular testing on all patients attending an infertility clinic. Full article
(This article belongs to the Special Issue Host–Microbe Interactions in Health and Disease)
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