Cutting-Edge 3D Printing Technology for Drug Delivery and Tissue Engineering

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmaceutical Technology, Manufacturing and Devices".

Deadline for manuscript submissions: 31 December 2025 | Viewed by 376

Special Issue Editors


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Guest Editor
Department of Physiological Sciences, Faculty of Medical and Health Sciences, Pontifical Catholic University of São Paulo, São Paulo, Sorocaba, Brazil
Interests: biomedical engineering; biomaterials; polimers; local delivery systems
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
Surgery Department, Faculty of Medical Sciences and Health, Pontifical Catholic University of São Paulo (PUC-SP), Rua Joubert Wey 290, São Paulo 18030-070, Sorocaba, Brazil
Interests: confocal microscopy; tissue engineering; bioresorbable materials; additive manufacture; molecular profiles by flow cytometry, biocompatibility, and cell differentiation

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Guest Editor
Laboratory of Biomaterials, Pontificial University Catholic (PUC), Sorocaba 18030-070, SP, Brazil
Interests: regenerative medicine; biomaterials; drug delivery systems; mesenchymal stem cells

Special Issue Information

Dear Colleagues,

Three-dimensional printing and tissue engineering are revolutionizing biomedical applications, leveraging advanced techniques like additive manufacturing to create complex structures that mimic tissue morphology, induce remodeling and healing, and produce customized implants or organ models, thereby enhancing precision in medical treatments. This innovative approach uses bioresorbable materials, with or without bioactive molecules, to construct scaffolds that support cell growth. State-of-the-art imaging plays a crucial role in this field, providing high-resolution views of the three-dimensional scaffolds designed to optimize these engineered tissues. The integration of bioresorbable materials ensures that these constructs gradually degrade as natural tissue regenerates, reducing the need for additional surgeries.

Recent advancements in drug delivery systems have further expanded the potential of 3D printing technology. By developing sophisticated delivery systems, when 3D biomaterials are associated with specific molecules or cells, these agents can be directly controlled and be induced by a sustained release to the target site. This approach not only enhances the effectiveness of the treatment but also minimizes systemic side effects and improves patient compliance. The ability to precisely control the spatial and temporal distribution of therapeutic agents within the printed constructs is paving the way for more effective and personalized treatments. It holds significant promise for advancing regenerative medicine and personalized healthcare, offering new solutions for previously untreatable conditions and improving patient outcomes.

I kindly invite you to contribute your groundbreaking research to our upcoming Special Issue, showcasing how 3D printing technology is transforming drug delivery and tissue engineering. This Special Issue aims to highlight biomedical applications through the use of additive manufacturing, bioresorbable materials, and state-of-the-art imaging techniques. Three-dimensional biomaterials, featuring the delivery of bioactive molecules, are strongly desired. Your expertise and innovative work in creating complex structures that mimic tissue morphology, induce remodeling and healing, and produce customized implants or organ models are invaluable to advancing our collective understanding and application of these technologies. By sharing your research, you can help shape the future of regenerative medicine and personalized healthcare, offering new solutions for previously untreatable conditions and improving patient outcomes.

We eagerly anticipate your contributions to this Special Issue and look forward to showcasing the remarkable advancements in this dynamic field.

Prof. Dr. Eliana Aparecida de Rezende Duek
Prof. Dr. Moema Hausen
Dr. Cecília de Barros
Guest Editors

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Keywords

  • additive manufacturing
  • smart materials
  • bioactive molecules
  • drug delivery systems
  • tissue engineering
  • biomaterials for tissue healing
  • 3D scaffolds
  • cell therapy with biomaterials

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Published Papers (1 paper)

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Research

18 pages, 2206 KiB  
Article
Innovative Use of Gallic Acid as a Crosslinking Agent for Gelatin: A Biocompatible Strategy for 3D-Printed Scaffolds in Tissue Engineering
by Teresa Carranza, Elias Hasan, Pedro Guerrero, Koro de la Caba and Ana Marina Ferreira
Pharmaceutics 2025, 17(8), 951; https://doi.org/10.3390/pharmaceutics17080951 (registering DOI) - 22 Jul 2025
Abstract
Background/Objectives: Gallic acid, a natural phenolic compound, was used as a crosslinking agent to achieve protein–polyphenol conjugation under alkaline conditions, presenting an innovative approach to stabilize gelatin. Methods: The formulated inks were evaluated for their rheological properties and 3D printing performance. Once the [...] Read more.
Background/Objectives: Gallic acid, a natural phenolic compound, was used as a crosslinking agent to achieve protein–polyphenol conjugation under alkaline conditions, presenting an innovative approach to stabilize gelatin. Methods: The formulated inks were evaluated for their rheological properties and 3D printing performance. Once the scaffolds were printed, physicochemical properties were assessed by color changes and FTIR. Additionally, three different post-processing methods were studied to avoid toxicity: incubation in PBS, incubation in NaOH followed by PBS neutralization, and incubation in HCl followed by PBS neutralization. Results: The inks exhibited shear-thinning behavior with self-supporting capacity after extrusion, indicating their suitability for use as inks in 3D printing. After printing, changes in color and in the amide I band/amide II band ratio were observed due to alkaline oxidation, confirming the gelatin crosslinking. Among the tested treatments, incubation in PBS or NaOH followed by neutralizing with PBS proved to be the most suitable for obtaining cytocompatible scaffolds. The mechanical properties demonstrated the suitability of the proposed crosslinking systems for creating scaffolds. Conclusions: This strategy confirms that gallic acid-mediated crosslinking under alkaline conditions enables the fabrication of cytocompatible and mechanically stable gelatin-based scaffolds, making them suitable for tissue engineering. Full article
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