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Pharmaceutics
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In Vitro and In Vivo Biopharmaceutics Assessment of Silica-Based Drug...
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In Vitro and In Vivo Biopharmaceutics Assessment of Silica-Based Drug Delivery Systems: Characterization, Drug Release, and Biological Performance

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biopharmaceutics".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 514

Special Issue Editor

Dr. Francisco Arriagada

E-Mail Website
Guest Editor
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380494, Chile
Interests: drug delivery; nanomedicine; topical; controlled release
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit your work to this Special Issue, entitled “In Vitro and In Vivo Biopharmaceutics Assessment of Silica-Based Drug Delivery Systems: Characterization, Drug Release, and Biological Performance”. This Special Issue aims to present a comprehensive overview of both in vitro and in vivo biopharmaceutics assessments of these innovative nanocarriers. We invite original research and review articles that focus on the detailed characterization of silica-based formulations, including morphology, porosity, and surface modifications, as well as research on drug release kinetics and biological performance.

Research areas may include (but are not limited to) the development of innovative methodologies for evaluating drug release kinetics; studies clarifying how experimental factors impact release profiles; and the design of porous materials for controlled release, including systems using silica as a core or as a coating on metal/organic nanoparticles. We also welcome research on surface modifications that modulate in vivo behavior, as well as comparative studies bridging in vitro techniques with in vivo performance, thereby advancing the field of biopharmaceutics.

Contributions addressing challenges and new perspectives in both method development and biological assessment are especially encouraged. Ultimately, this Special Issue seeks to pave the way for improved drug delivery outcomes.

Dr. Francisco Arriagada
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • drug delivery systems
  • mesoporous silica nanoparticles
  • biopharmaceutics evaluation
  • controlled drug release
  • drug release kinetics
  • in vivo performance
  • in vitro methodologies
  • pharmaceutical nanotechnology
  • stimuli-responsive systems
  • therapeutic efficacy

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Published Papers (1 paper)

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Research

17 pages, 4722 KiB  
Article
Kinetic and Methodological Insights into Hydrophilic Drug Release from Mesoporous Silica Nanocarriers
by Rodrigo Rozas, Andrea C. Ortiz, Sofía Peñaloza, Sebastián Lizama, Mario E. Flores, Javier Morales and Francisco Arriagada
Pharmaceutics 2025, 17(6), 694; https://doi.org/10.3390/pharmaceutics17060694 - 25 May 2025
Viewed by 410
Abstract
Background/Objectives: The absence of standardized protocols for assessing in vitro drug release from nanocarriers poses significant challenges in nanoformulation development. This study evaluated three in vitro methods: sample and separate without medium replacement (independent batch), sample and separate with medium replacement, and a [...] Read more.
Background/Objectives: The absence of standardized protocols for assessing in vitro drug release from nanocarriers poses significant challenges in nanoformulation development. This study evaluated three in vitro methods: sample and separate without medium replacement (independent batch), sample and separate with medium replacement, and a dialysis bag method, to characterize the release of rhodamine B from mesoporous silica nanoparticles (MSNs). Methods: Each method was examined under varying agitation conditions (shaking versus stirring). MSNs were synthesized via the sol-gel method, exhibiting a hydrodynamic diameter of 202 nm, a zeta potential of −23.5 mV, and a surface area of 688 m2/g, with a drug loading efficiency of 32.4%. Results: Release profiles revealed that the independent batch method exhibited a rapid initial burst followed by a plateau after 4 h, attributed to surface saturation effects. Conversely, the sample and separate with medium replacement method sustained the release up to 60% over 48 h, maintaining sink conditions. The dialysis method showed agitation-dependent variability, with magnetic stirring using a longer stir bar enhancing release. Kinetic analyses indicated first-order kinetics with non-Fickian diffusion. Conclusions: Overall, the results indicate that both the selection of the in vitro method and the agitation technique play a crucial role in determining the apparent drug release kinetics from nanocarriers. These findings highlight the critical role of experimental design in interpreting nanocarrier release kinetics, advocating for tailored protocols to improve reproducibility and in vitro–in vivo correlations in nanoformulation. Full article
(This article belongs to the Special Issue In Vitro and In Vivo Biopharmaceutics Assessment of Silica-Based Drug Delivery Systems: Characterization, Drug Release, and Biological Performance)
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