Nanosystems for Advanced Diagnostics and Therapy

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".

Deadline for manuscript submissions: 30 November 2025 | Viewed by 391

Special Issue Editors


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Guest Editor
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380494, Chile
Interests: drug delivery; nanomedicine; topical; controlled release
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Department of Pharmaceutical Science and Technology, School of Chemical and Pharmaceutical Sciences, University of Chile, Santiago 8380494, Chile
Interests: animal models; nanotechnology; polymer thin films; buccal administration; chromatography; casting; manufacturing; peptides; dosage forms; nanoparticles; nanomedicine
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to submit your work to this Special Issue on “Nanosystems for Advanced Diagnostics and Therapy”. By combining nanotechnology with biomedical science, researchers have developed innovative nanosystems that boost diagnostic accuracy and improve treatment effectiveness. This Special Issue will showcase the latest breakthroughs in nanoscale technologies for medical imaging, disease detection, drug delivery, and theranostics.

We welcome original research articles and detailed reviews that explore the design, characterization, and application of nanosystems such as lipid-based nanoparticles, polymeric carriers, inorganic nanostructures, and hybrid platforms. We are particularly interested in systems enabling targeted drug delivery, image-guided therapy, multimodal imaging, or responsive behavior in biological environments.

Topics of interest include, but are not limited to, the following:

  • Development of smart delivery vehicles;
  • Fine-tuning nanosystem properties for enhanced bioavailability or selectivity;
  • Integration of diagnostic and therapeutic functionalities (theranostics);
  • In vitro and in vivo evaluation and translational challenges;
  • Radiolabeling strategies for molecular imaging.

This Special Issue aims to foster innovation at the intersection of pharmaceutical sciences, nanomedicine, and molecular imaging.

Dr. Francisco Arriagada
Dr. Javier Morales
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • nanosystems
  • theranostics
  • nanomedicine
  • molecular imaging
  • targeted drug delivery
  • radiolabeled nanoparticles
  • image guided therapy
  • smart nanocarriers
  • nanoradiopharmaceuticals
  • nanotechnology in diagnostics

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Published Papers (1 paper)

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Review

34 pages, 4581 KiB  
Review
Nanoradiopharmaceuticals: Design Principles, Radiolabeling Strategies, and Biomedicine Applications
by Andrés Núñez-Salinas, Cristian Parra-Garretón, Daniel Acuña, Sofía Peñaloza, Germán Günther, Soledad Bollo, Francisco Arriagada and Javier Morales
Pharmaceutics 2025, 17(7), 912; https://doi.org/10.3390/pharmaceutics17070912 - 14 Jul 2025
Viewed by 294
Abstract
Nanoradiopharmaceuticals integrate nanotechnology with nuclear medicine to enhance the precision and effectiveness of radiopharmaceuticals used in diagnostic imaging and targeted therapies. Nanomaterials offer improved targeting capabilities and greater stability, helping to overcome several limitations. This review presents a comprehensive overview of the fundamental [...] Read more.
Nanoradiopharmaceuticals integrate nanotechnology with nuclear medicine to enhance the precision and effectiveness of radiopharmaceuticals used in diagnostic imaging and targeted therapies. Nanomaterials offer improved targeting capabilities and greater stability, helping to overcome several limitations. This review presents a comprehensive overview of the fundamental design principles, radiolabeling techniques, and biomedical applications of nanoradiopharmaceuticals, with a particular focus on their expanding role in precision oncology. It explores key areas, including single- and multi-modal imaging modalities (SPECT, PET), radionuclide therapies involving beta, alpha, and Auger emitters, and integrated theranostic systems. A diverse array of nanocarriers is examined, including liposomes, micelles, albumin nanoparticles, PLGA, dendrimers, and gold, iron oxide, and silica-based platforms, with an assessment of both preclinical and clinical research outcomes. Theranostic nanoplatforms, which integrate diagnostic and therapeutic functions within a single system, enable real-time monitoring and personalized dose optimization. Although some of these systems have progressed to clinical trials, several obstacles remain, including formulation stability, scalable manufacturing, regulatory compliance, and long-term safety considerations. In summary, nanoradiopharmaceuticals represent a promising frontier in personalized medicine, particularly in oncology. By combining diagnostic and therapeutic capabilities within a single nanosystem, they facilitate more individualized and adaptive treatment approaches. Continued innovation in formulation, radiochemistry, and regulatory harmonization will be crucial to their successful routine clinical use. Full article
(This article belongs to the Special Issue Nanosystems for Advanced Diagnostics and Therapy)
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