Metabolism and Clearance of Nanomaterials and Engineered Delivery Systems
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Nanomedicine and Nanotechnology".
Deadline for manuscript submissions: 20 May 2026 | Viewed by 941
Special Issue Editor
Interests: nanoparticle delivery; asthma; immunogenic compounds
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
The exploration of nanoparticles for the purpose of cargo delivery of therapeutics to the body is a hot topic, but what happens after the medicine is delivered? While chemical medicines are processed via the cytochrome, bile, and enzymatic pathways in the liver, nanoparticles may also be directly excreted via the kidneys. In these situations, particle size and composition play major roles in the excretory capability of nanopackaging, and engineered systems must find a proper biochemical compromise between retention (to maintain therapeutic effect) and elimination.
If excretory mechanisms are ineffective at clearing particles, bioaccumulation within the body may be a serious concern, especially in patients with impaired kidney or liver function, and this can lead to cytotoxicity concerns. Specific organs targeted by nanomedicine accumulation over time could, thus, bear a high and sustained burden of drug elimination. Additionally, partially metabolized nanoparticles may bioaccumulate in waste disposal networks and negatively affect fish and wildlife in the broader environment. Thus, the biochemical mechanisms driving the metabolism and clearance of these delivery systems are key for the realistic integration of nanomedicine into treatment development.
For this Special Issue, we invite manuscripts that explore the mechanisms of metabolism of the nanomaterials used to deliver therapeutics to the body, focusing on whole-organ systems and how specific targets of nanomedicines clear packaging once therapy is delivered. We welcome all studies on the metabolism and clearance of nanomaterials and other engineered medical delivery systems, with an emphasis on renal and hepatic clearance at the cellular level.
Dr. Bryan Mathis
Guest Editor
Manuscript Submission Information
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Keywords
- nanoparticle
- pharmacokinetics
- metabolic clearance rate
- drug elimination routes
- biotransformation
- tissue distribution
- renal elimination
- hepatobiliary elimination
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