Design, Development and Biomedical Applications of Hyaluronic Acid-Based Drug and Gene Delivery Systems
A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: 31 October 2025 | Viewed by 36
Special Issue Editors
Interests: biomaterials; polymer synthesis; hydrogels; nanoparticles; gene and drug delivery; therapeutics stability
Special Issues, Collections and Topics in MDPI journals
2. Max Planck Institute of Molecular Cell Biology and Genetics, Pfotenhauerstrasse 108, 01307 Dresden, Germany
Interests: drug delivery; nanomedicine; RNA therapeutics; polymeric nanoparticles; lipid nanoparticles; endosomal escape
Special Issue Information
Dear Colleagues,
Hyaluronic acid (HA) has emerged as a powerful tool in biomedical applications, particularly in drug and gene delivery. Its biocompatibility, biodegradability and ability to interact with receptors such as CD44 make it ideal for targeted delivery strategies. HA-based systems—ranging from nanoparticles to hydrogels—have shown promise in improving therapeutic efficacy, reducing off-target effects, prolonging drug circulation time and enabling precise targeting in cancer and inflammation.
This Special Issue aims to highlight the latest advances in the design and development of HA-based carriers for the delivery of small molecules, nucleic acids and biologics. We invite original research and review articles focusing on the synthesis, functionalization and characterization of HA-based materials, their biological performance and translational potential.
By bringing together innovative approaches in HA engineering and application, this Special Issue will contribute to the growing field of targeted and responsive drug/gene delivery.
We look forward to hearing from you.
Dr. Cristina Casadidio
Dr. Alice Spadea
Guest Editors
Manuscript Submission Information
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Keywords
- hyaluronic acid
- targeted drug delivery
- gene delivery
- CD44
- nucleic acid delivery
- HA conjugates
- nanoparticles personalized medicine
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