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Pharmaceutics
Special Issues
Delivery Systems on the Antioxidant Activity of Natural Bioactive Compounds
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Delivery Systems on the Antioxidant Activity of Natural Bioactive Compounds

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Biologics and Biosimilars".

Deadline for manuscript submissions: 31 May 2024 | Viewed by 2240

Special Issue Editors

Dr. Florentina Gatea

E-Mail Website
Guest Editor
Institutul National de Cercetare - Dezvoltare pentru Stiinte Biologice, Bucuresti, Bucharest, Romania
Interests: natural extracts; bioavailability; delivery system for antioxidants; oxidative stress
Prof. Dr. Emanuel Vamanu

E-Mail Website
Guest Editor
Faculty of Biotechnology, University of Agricultural Sciences and Veterinary Medicine, 011464 Bucharest, Romania
Interests: microbiota; oxidative stress; in vitro; antioxidant; natural compounds; fermentation; healthy beverages; vegan supplements; non dairy products
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural compounds are a source of antioxidants for all living organisms. The mechanisms by which they act at the cellular level are fairly renowned, but in order to manifest their activity, to contribute to the reduction in oxidative stress, and to implicitly reduce the chances of developing chronic diseases, they must reach the cellular level. The main sources of antioxidants are food (fruits, vegetables, teas, coffee, and mushrooms) and dietary supplements. Many of these compounds are degraded and/or transformed as they pass through the digestive tract and most of them are excreted. Due to these reasons, finding new transport and delivery systems for antioxidants is an up-to-date research direction with immediate benefits. Moreover, the modulation process of the microbiota fingerprint represents an interesting way of enhancing the functional properties and bioavailability of certain bioactive compounds. These aspects are important for large groups of the population affected by chronic diseases and potentiate the classic medication.

In this Special Issue, called "Delivery Systems on the Antioxidant Activity of Natural Bioactive Compounds", authors are invited to present original research articles, review papers, clinical case reports, or communications.

Dr. Florentina Gatea
Prof. Dr. Emanuel Vamanu
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural extracts
  • bioavailability
  • modulation
  • delivery system for antioxidants
  • antioxidants
  • biodisponibility
  • oxidative stress

Published Papers (2 papers)

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Research

16 pages, 2323 KiB  
Article
Vanillin Promotes Osteoblast Differentiation, Mineral Apposition, and Antioxidant Effects in Pre-Osteoblasts
by Hyung-Mun Yun, Eonmi Kim, Yoon-Ju Kwon and Kyung-Ran Park
Pharmaceutics 2024, 16(4), 485; https://doi.org/10.3390/pharmaceutics16040485 - 01 Apr 2024
Viewed by 476
Abstract
Antioxidant vanillin (4-hydroxy-3-methoxybenzaldehyde) is used as a flavoring in foods, beverages, and pharmaceuticals. Vanillin possesses various biological effects, such as antioxidant, anti-inflammatory, antibacterial, and anticancer properties. This study aimed to investigate the biological activities of vanillin purified from Adenophora triphylla var. japonica Hara [...] Read more.
Antioxidant vanillin (4-hydroxy-3-methoxybenzaldehyde) is used as a flavoring in foods, beverages, and pharmaceuticals. Vanillin possesses various biological effects, such as antioxidant, anti-inflammatory, antibacterial, and anticancer properties. This study aimed to investigate the biological activities of vanillin purified from Adenophora triphylla var. japonica Hara on bone-forming processes. Vanillin treatment induced mineralization as a marker for mature osteoblasts, after stimulating alkaline phosphatase (ALP) staining and activity. The bone-forming processes of vanillin are mainly mediated by the upregulation of the bone morphogenetic protein 2 (BMP2), phospho-Smad1/5/8, and runt-related transcription factor 2 (RUNX2) pathway during the differentiation of osteogenic cells. Moreover, vanillin promoted osteoblast-mediated bone-forming phenotypes by inducing migration and F-actin polymerization. Furthermore, we validated that vanillin-mediated bone-forming processes were attenuated by noggin and DKK1. Finally, we demonstrated that vanillin-mediated antioxidant effects prevent the death of osteoblasts during bone-forming processes. Overall, vanillin has bone-forming properties through the BMP2-mediated biological mechanism, indicating it as a bone-protective compound for bone health and bone diseases such as periodontitis and osteoporosis. Full article
(This article belongs to the Special Issue Delivery Systems on the Antioxidant Activity of Natural Bioactive Compounds)
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14 pages, 4092 KiB  
Article
A Facile Synthesis of Flower-like Iron Oxide Nanoparticles and Its Efficacy Measurements for Antibacterial, Cytotoxicity and Antioxidant Activity
by Nazish Tabassum, Virendra Singh, Vivek K. Chaturvedi, Emanuel Vamanu and Mohan P. Singh
Pharmaceutics 2023, 15(6), 1726; https://doi.org/10.3390/pharmaceutics15061726 - 14 Jun 2023
Cited by 4 | Viewed by 1349
Abstract
The objective of this study was to investigate the rhombohedral-structured, flower-like iron oxide (Fe2O3) nanoparticles that were produced using a cost-effective and environmentally friendly coprecipitation process. The structural and morphological characteristics of the synthesized Fe2O3 nanoparticles [...] Read more.
The objective of this study was to investigate the rhombohedral-structured, flower-like iron oxide (Fe2O3) nanoparticles that were produced using a cost-effective and environmentally friendly coprecipitation process. The structural and morphological characteristics of the synthesized Fe2O3 nanoparticles were analyzed using XRD, UV-Vis, FTIR, SEM, EDX, TEM, and HR-TEM techniques. Furthermore, the cytotoxic effects of Fe2O3 nanoparticles on MCF-7 and HEK-293 cells were evaluated using in vitro cell viability assays, while the antibacterial activity of the nanoparticles against Gram-positive and Gram-negative bacteria (Staphylococcus aureus, Escherichia coli, and Klebsiella pneumoniae) was also tested. The results of our study demonstrated the potential cytotoxic activity of Fe2O3 nanoparticles toward MCF-7 and HEK-293 cell lines. The antioxidant potential of Fe2O3 nanoparticles was evidenced by the 1,1-diphenyl-2-picrylhydrazine (DPPH) and nitric oxide (NO) free radical scavenging assays. In addition, we suggested that Fe2O3 nanoparticles could be used in various antibacterial applications to prevent the spread of different bacterial strains. Based on these findings, we concluded that Fe2O3 nanoparticles have great potential for use in pharmaceutical and biological applications. The effective biocatalytic activity of Fe2O3 nanoparticles recommends its use as one of the best drug treatments for future views against cancer cells, and it is, therefore, recommended for both in vitro and in vivo in the biomedical field. Full article
(This article belongs to the Special Issue Delivery Systems on the Antioxidant Activity of Natural Bioactive Compounds)
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