Innovative Applications of Targeted Nanocarriers and Photodynamic Therapy in the Treatment of Neurological Diseases and Tumors

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: 31 March 2026 | Viewed by 1180

Special Issue Editors


E-Mail Website
Guest Editor
Laboratorio de Neurofarmacología Molecular y Nanotecnología, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, Mexico City 14269, Mexico
Interests: nanomaterials; brain tumors; drug delivery; nano-photosensitizsers; reactive oxygen species; photodynamic therapy
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Laboratorio Experimental de Enfermedades Neurodegenerativas, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, México City 14269, México
Interests: neurodegeneration; Alzheimer disease; epilepsy; Parkinson; tau protein; amyloid b
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
Laboratorio de neurofarmacología Molecular y Nanotecnología, Instituto Nacional de Neurología y Neurocirugía, Manuel Velasco Suárez, México City 14269, México
Interests: neurodegenerative diseases; cancer; nanomedicine; green synthesis of nanoparticles
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The treatment of neurological disorders such as neurodegenerative diseases and brain tumors remains challenging because the presence of the blood–brain barrier (BBB) renders treatments ineffective, as many potentially therapeutic drugs cannot enter the brain at therapeutic levels. As a result, new therapeutic strategies are urgently needed to overcome these problems and to cure diseases definitively without causing side effects. Photodynamic therapy has emerged as a promising alternative due to its anticancer efficacy and drug conjugation for targeted drug delivery using nanomaterials. Therefore, it is of interest to understand the current potential of photodynamic therapy as a nanotherapy for the treatment of neurological disorders. In addition to understanding its advantages, it is also important to understand its disadvantages in order to gain a perspective on its feasibility and challenges in the face of mainly neurodegenerative diseases and brain tumors.

Dr. Emma Ortiz-Islas
Dr. Victoria Campos-Peña
Dr. Citlali Ekaterina Rodríguez Pérez
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • photodynamic therapy
  • neurological disorders
  • targeted nanocarriers
  • brain tumors
  • Alzheimer’s disease
  • nanomedicine
  • drug delivery
  • reactive oxygen species
  • nano-photosensitizers

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Select all
Export citation of selected articles as:

Review

28 pages, 2193 KB  
Review
Photodynamic Therapy for Glioblastoma: Potential Application of TiO2 and ZnO Nanoparticles as Photosensitizers
by Emma Ortiz-Islas, María Elena Manríquez-Ramírez, Pedro Montes, Citlali Ekaterina Rodríguez-Pérez, Elizabeth Ruiz-Sanchez, Karla Carvajal-Aguilera and Victoria Campos-Peña
Pharmaceutics 2025, 17(9), 1132; https://doi.org/10.3390/pharmaceutics17091132 - 29 Aug 2025
Viewed by 944
Abstract
Despite aggressive current therapies against glioblastoma (GB), residual tumor cells may remain at the edge of the surgical cavity after resection. These cells can rapidly proliferate, giving rise to tumor recurrence in more aggressive and drug-resistant forms. As photodynamic therapy (PDT) has advanced, [...] Read more.
Despite aggressive current therapies against glioblastoma (GB), residual tumor cells may remain at the edge of the surgical cavity after resection. These cells can rapidly proliferate, giving rise to tumor recurrence in more aggressive and drug-resistant forms. As photodynamic therapy (PDT) has advanced, it has emerged as an option to treat this brain tumor. The oncological basis of PDT involves the selective accumulation of a photosensitizer (PS) in the tumor, followed by its activation with electromagnetic radiation to generate reactive oxygen species (ROS), which induce tumor cell death. Given that first- and second-generation PSs present significant limitations, including poor tumor selectivity, suboptimal biodistribution, limited absorption within the therapeutic window, and slow systemic clearance, research has progressed toward the development of third-generation PSs based on nanotechnology to optimize their therapeutic properties. This review addresses the types of tumor cell death induced by PDT, as well as the advancements of PS design, focusing on titanium dioxide (TiO2) and zinc oxide (ZnO) nanoparticles. These nanomaterials can be designed as carriers, encapsulating or conjugating conventional PSs, or act as PSs themselves, due to their favorable biocompatibility and intrinsic photoreactivity. Additionally, they can be functionalized with targeting ligands to achieve tumor-specific delivery, enhancing therapeutic selectivity while minimizing toxicity to healthy tissue. Overall, these nanotechnology-based PSs represent a versatile and promising therapeutic paradigm that warrants further investigation through basic research, supporting the development and potential clinical translation of a more precise and effective PDT-based intervention for glioblastoma, initially aimed at eliminating intra-surgical post-resection residual tumor cells. Full article
Show Figures

Figure 1

Back to TopTop