Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
10.0
5.5
Journals
Pharmaceutics
Special Issues
Advancements in Tablet Formulation and Technological Innovations in Pharmaceutical Manufacturing
share announcement

Advancements in Tablet Formulation and Technological Innovations in Pharmaceutical Manufacturing

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 April 2026 | Viewed by 1490

Special Issue Editors

Prof. Dr. Krzysztof Cal

E-Mail Website
Guest Editor
Department of Pharmaceutical Technology, Faculty of Pharmacy, Medical University of Gdansk, 80-416 Gdansk, Poland
Interests: pharmaceutical technology; oral dosage forms; skin penetration and permeation
Special Issues, Collections and Topics in MDPI journals
Dr. Daniel Zakowiecki

E-Mail Website
Guest Editor
Chemische Fabrik Budenheim KG, Rheinstrasse 27, 55257 Budenheim, Germany
Interests: pharmaceutical technology; formulation development; direct compression; excipients; OSDF; improvement of drug solubility; pharmaceutical analysis
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Despite the significant advancements in pharmaceutical technology and the development of novel drug delivery systems, conventional solid dosage forms, such as tablets or capsules, remain the most widely produced and trusted by patients. Their manufacturing is influenced not only by technological processes but also by the selection of excipients within the formulation. These factors enhance product quality, boost production efficiency, and lower overall costs.

Nevertheless, with increasing market competition and the need for cost-effective manufacturing strategies, advances in efficiency, drug quality, and safety remain crucial for the sustainability of pharmaceutical companies. A comprehensive understanding of formulations and manufacturing processes is therefore essential.

This Special Issue highlights the recent advancements in the design and manufacture of oral solid dosage forms. It summarizes cutting-edge research that deepens the understanding of manufacturing processes for tablets, capsules, granules, powders, and related formulations. Of particular interest are modern and complex forms, such as multi-layer tablets or combination drugs, etc., which pose unique challenges and opportunities in pharmaceutical development.

You may choose our Joint Special Issue in Journal of Pharmaceutical and BioTech Industry.

Prof. Dr. Krzysztof Cal
Dr. Daniel Zakowiecki
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • tablets
  • capsules
  • granules
  • powders
  • oral solid dosage forms
  • OSDF
  • pharmaceutical technology
  • direct compression
  • granulation
  • pharmaceutical manufacturing
  • excipients

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • Reprint: MDPI Books provides the opportunity to republish successful Special Issues in book format, both online and in print.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (2 papers)

Download All Papers
Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 1851 KB  
Article
Impact of Different Drying Processes on the Physico-Chemical Properties of Liquitablet Formulations Containing Lornoxicam
by Csilla Balla-Bartos, Alaa Gamiel, Anett Motzwickler-Németh and Rita Ambrus
Pharmaceutics 2025, 17(9), 1096; https://doi.org/10.3390/pharmaceutics17091096 - 22 Aug 2025
Viewed by 348
Abstract
Background: Enhancing bioavailability is the target of most pharmaceutical research; this can be achieved by modifying the physico-chemical characteristics of poorly water-soluble drugs intended for oral administration using different techniques. The preparation of liquitablets by blister molding technique provides an opportunity to [...] Read more.
Background: Enhancing bioavailability is the target of most pharmaceutical research; this can be achieved by modifying the physico-chemical characteristics of poorly water-soluble drugs intended for oral administration using different techniques. The preparation of liquitablets by blister molding technique provides an opportunity to increase the bioavailability of the drug using an optimal combination of release-facilitating additives. Lornoxicam is an effective non-steroidal anti-inflammatory drug with low water solubility. This study aimed to formulate a novel lornoxicam-containing liquitablets. The effect of different drying techniques on the physico-chemical properties and in vitro dissolution of lornoxicam was investigated. The physical parameters of the tablets were also studied. Methods: The additives applied in the formulation included Tween® 80, Polyvinylpyrrolidone (PVP K90), Avicel® PH-102, and sodium bicarbonate. Vacuum-drying and freeze-drying were employed to produce liquitablets. The influence of various drying methods on crystallinity and intra- and interparticle phenomena was investigated. In Vitro dissolution tests were performed at pH 1.2, and a comparison was made between our products and commercial tablets using the pairwise similarity factor model (f2). Results: The liquitablets demonstrated high hydrophilicity and a lower crystallinity of the drug. Freeze-dried liquitablet showed improved dissolution compared to that of the pure drug or the vacuum-dried product. A similarity was observed between our freeze-dried product and the marketed fast-release tablets. Conclusions: This research demonstrates that preparation of liquitablet in combination with freeze-drying has a significantly positive effect in improving the in vitro dissolution rate of lornoxicam. Full article
(This article belongs to the Special Issue Advancements in Tablet Formulation and Technological Innovations in Pharmaceutical Manufacturing)
►▼ Show Figures

Graphical abstract

19 pages, 5085 KB  
Article
Fabrication and Evaluation of Isomalt-Based Microfibers as Drug Carrier Systems
by Andrea Kovács, Bálint Attila Kecskés, Gábor Filipszki, Dóra Farkas, Bence Tóth, István Antal and Nikolett Kállai-Szabó
Pharmaceutics 2025, 17(8), 1063; https://doi.org/10.3390/pharmaceutics17081063 - 15 Aug 2025
Viewed by 552
Abstract
Background/Objectives: The melt-spinning process has seen limited application in the pharmaceutical industry. However, nano- and microfibrous structures show significant potential for novel drug delivery systems, due to their high specific surface area. To facilitate broader adoption in pharmaceutical technology, critical parameters influencing [...] Read more.
Background/Objectives: The melt-spinning process has seen limited application in the pharmaceutical industry. However, nano- and microfibrous structures show significant potential for novel drug delivery systems, due to their high specific surface area. To facilitate broader adoption in pharmaceutical technology, critical parameters influencing fiber quality and yield must be investigated. In this study, we aimed to develop an isomalt-based microfibrous carrier system for active pharmaceutical ingredients. Methods: The effects of different isomalt compositions—specifically, varying ratios of GPS (6-O-α-d-glucopyranosyl-d-sorbitol) and GPM (1-O-α-d-glucopyranosyl-d-mannitol)—as well as key process parameters, were systematically investigated to optimize fiber formation. The prepared fibers underwent different treatments. Morphological changes were monitored with a microscope, and microstructural changes were studied using a differential scanning calorimeter and X-ray diffractometer. The macroscopic behavior of the fibers was evaluated by image analysis under monitored conditions. Results: Statistical analysis was used to determine the optimal setting to produce isomalt-based fibers. We found that storage over ethanol vapor has a positive effect on the stability of the fibers. We successfully prepared ibuprofen sodium-containing fibers that remained stable after alcohol treatment and enabled drug release within 15 s. Conclusions: It was found that the applied GPS:GPM isomalt ratio significantly influenced fiber formation and that storage over ethanol positively influenced the processability and stability of the fibrous structure. An isomalt-based microfibrous system with advantageous physicochemical and structural properties was successfully developed as a potential drug carrier. The system is also resistant to the destructive effects of ambient humidity, enabling preparation of suitable dosage forms. Full article
(This article belongs to the Special Issue Advancements in Tablet Formulation and Technological Innovations in Pharmaceutical Manufacturing)
►▼ Show Figures

Graphical abstract

Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-2
Back to TopTop