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Pharmaceutics
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Solid Dispersions for Drug Delivery: Development, Preparation and In Vitro/In...
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Solid Dispersions for Drug Delivery: Development, Preparation and In Vitro/In Vivo Characterization

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: closed (31 July 2025) | Viewed by 3611

Special Issue Editor

Dr. Anna Czajkowska-Kośnik

E-Mail Website
Guest Editor
Department of Pharmaceutical Technology, Medical University of Białystok, Mickiewicza 2c, 15-222 Białystok, Poland
Interests: solid dispersions; lipid carriers; low solubility; pharmaceutical technology; topical drug delivery; formulation and characterization of dosage forms; drug release; skin permeation
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Solid dispersion is one of the effective approaches for drugs characterized by poor solubility. Many polymers with various physicochemical and thermochemical properties are utilized to prepare the solid dispersions, in which drugs can be dispersed as separate molecules, amorphous particles, or crystalline particles in the crystalline or amorphous carrier. Numerous studies on solid dispersions have been published and have shown the many advantageous of solid dispersions in enhancing drug solubility, improving stability and modifying its release. These advantages include reducing particle size and enhancing wettability and porosity, as well as changing the drug crystalline state, preferably into the amorphous state. Solid dispersions can be prepared by various methods, e.g., solvent evaporation, spray drying, hot melt extrusion, ball milling, freeze-drying or electrospinning, and then can be examined using different analytical and instrumental methods to assess their features (solubility, dissolution rate, physical state of drug, stability, drug–polymer interactions, morphology).

We are pleased to invite you to submit articles on the latest advances in solid dispersions for drug delivery. In the submitted article, readers will find new information about solid dispersions, focusing on their development, preparation, stability assessment and evaluation of their properties. Studies offering innovative methodologies, use of novel polymers and new applications of solid dispersions are highly welcome.

We look forward to receiving your contributions.

Dr. Anna Czajkowska-Kośnik
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • solid dispersion
  • poorly soluble drugs
  • stability
  • dissolution properties
  • molecular interaction
  • polymers

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Published Papers (2 papers)

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Research

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13 pages, 1069 KiB  
Article
Cyclosporine Dissolution Test from a Lipid Dosage Form: Next Step Towards the Establishment of Release Method for Solid Lipid Microparticles
by Eliza Wolska, Patrycja Dudek and Małgorzata Sznitowska
Pharmaceutics 2025, 17(8), 1030; https://doi.org/10.3390/pharmaceutics17081030 - 8 Aug 2025
Viewed by 205
Abstract
Background: The release study is a standard tool for the development, evaluation, and control of dosage forms. In the case of traditional drug delivery systems, it is conducted in accordance with the established principles available in the European and American Pharmacopoeias or guidelines [...] Read more.
Background: The release study is a standard tool for the development, evaluation, and control of dosage forms. In the case of traditional drug delivery systems, it is conducted in accordance with the established principles available in the European and American Pharmacopoeias or guidelines proposed by registration agencies. The problem is the study of modern carriers, not yet described in compendia, which require adjustments to traditionally used methods. Objectives: The present study focuses on developing an optimal method for testing the release of cyclosporine (Cs, 0.5–4%) incorporated in solid lipid microparticles (SLM) dispersions (10%) intended for administration in the form of eye drops. This is a multicompartment lipid carrier that provides prolonged release of the active substance. Methods: Three methods of testing the release were compared: the dialysis bag method, the horizontal cells technique, and a method without a membrane. Results: During the analyses, the proper membrane was selected and the effect of the lysozyme enzyme on the release profile was analyzed. The effect of the composition of the acceptor fluid on the obtained results was also assessed. In the model without a membrane, up to 60% of the Cs was released within 30 min due to the burst effect. In horizontal chambers, no formulation released more than 14% of the Cs over 96 h, while at the same time, 60–70% of the Cs was released from the dialysis bag. Conclusions: Based on the obtained results, the dialysis bag method was selected to study the release of Cs from SLM without the need to use multicomponent artificial tear fluid as an acceptor medium. Full article
(This article belongs to the Special Issue Solid Dispersions for Drug Delivery: Development, Preparation and In Vitro/In Vivo Characterization)
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Review

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30 pages, 933 KiB  
Review
Hydroxypropyl Methylcellulose—A Key Excipient in Pharmaceutical Drug Delivery Systems
by Robert-Alexandru Vlad, Andrada Pintea, Cezara Pintea, Emőke-Margit Rédai, Paula Antonoaea, Magdalena Bîrsan and Adriana Ciurba
Pharmaceutics 2025, 17(6), 784; https://doi.org/10.3390/pharmaceutics17060784 - 16 Jun 2025
Cited by 1 | Viewed by 3133
Abstract
Hydroxypropyl methylcellulose (Hypromellose, HPMC) is a well-known excipient used in the pharmaceutical and nutraceutical fields due to its versatile physicochemical properties. HPMC (derived from cellulose and obtained through etherification) varies in polymerization degree and viscosity, factors that both influence its functional applications. Usually, [...] Read more.
Hydroxypropyl methylcellulose (Hypromellose, HPMC) is a well-known excipient used in the pharmaceutical and nutraceutical fields due to its versatile physicochemical properties. HPMC (derived from cellulose and obtained through etherification) varies in polymerization degree and viscosity, factors that both influence its functional applications. Usually, an increased polymerization degree implies a higher viscosity, depending also on the amount of polymer used. Hypromellose plays a crucial role in solid dosage forms, serving as a binder in the case of controlled-release tablets, a film-forming agent in the case of orodispersible films and mucoadhesive films, and a release modifier due to its presence in different polymerization degrees in the case of extended or modified release tablets. However, its compatibility with other excipients and the active ingredient must be carefully evaluated to prevent formulation challenges via several analytical methods such as differential scanned calorimetry (DSC), Fourier Transformed Infrared spectroscopy (FT-IR), X-Ray Particle Diffraction (XRPD), and Scanning Electron Microscopy (SEM). This review explores the physicochemical characteristics, and diverse applications of HPMC, emphasizing its significance in modern drug delivery systems. Full article
(This article belongs to the Special Issue Solid Dispersions for Drug Delivery: Development, Preparation and In Vitro/In Vivo Characterization)
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