Advances in Anticancer Drug Metabolism Research: Implications for Personalized Therapeutics

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Pharmacokinetics and Pharmacodynamics".

Deadline for manuscript submissions: closed (31 October 2025) | Viewed by 1975

Special Issue Editors


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LAQV/REQUIMTE, Laboratory of Bromatology and Hidrology, Department of Chemical Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
Interests: cardio-oncology; anticancer drugs; cardiotoxicity; in vivo; in vitro; molecular biology; inflammation; oxidative stress; metabolism; biotransformation

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LAQV/REQUIMTE, Laboratory of Pharmacology, Department of Drug Sciences, Faculty of Pharmacy, University of Porto, 4050-313 Porto, Portugal
Interests: pharmacology; metal-based drugs; in vitro; in vivo; oncology; pharmacokinetics; anticancer drugs; biomarkers
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Faculty of Health Sciences, University Fernando Pessoa, Rua Carlos da Maia, 4200-150 Porto, Portugal
Interests: toxicology; drugs of abuse; amphetamines; synthetic cathinones; psychoactive substances; toxicometabolomics; cancer metabolomics; biomarkers; hepatotoxicity; nephrotoxicity; cardiotoxicity; oxidative stress
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Research Institute for Medicines (iMed.ULisboa), Faculty of Pharmacy, University of Lisbon, 1649-003 Lisbon, Portugal
Interests: phenolic compounds; immunometabolism; food nanotechnologies; nanoencapsulation; drug delivery systems; biodisponibility; colorectal cancerolic compounds; persimmon; food science; functional foods; biochemistry; haematology; in vitro/in vivo inflammation and cancer models
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

We are pleased to invite you to contribute to the launch of a Special Issue titled "Advances in Anticancer Drug Metabolism Research: Implications for Personalized Therapeutics". This Special Issue aims to underscore the critical role of drug metabolism in determining the efficacy and safety of anticancer therapies. A deeper understanding of metabolic pathways and the genetic factors influencing drug biotransformation is essential for optimizing therapeutic outcomes and driving the development of personalized medicines.

We welcome original research articles and comprehensive reviews on a variety of topics, including, but not limited to, the following:

  • Metabolic pathways of anticancer drugs;
  • Pharmacogenomics and precision oncology;
  • Drug–drug interactions in cancer therapies;
  • Biomarkers of drug response and/or toxicity;
  • Emerging therapeutic targets and innovative strategies.

Submissions exploring interdisciplinary approaches that increase our understanding of drug metabolism's impact on personalized cancer treatment are particularly welcome. These collaborations have the potential to drive significant advancements in improving patient outcomes, encompassing survival rates and quality of life.

We look forward to your contributions to this Special Issue, thus enhancing the field of anticancer drug metabolism research and its translation into tailored therapeutic strategies.

Dr. Ana Reis-Mendes
Dr. Martin Vojtek
Dr. Márcia Carvalho
Dr. Rosa Direito
Guest Editors

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Keywords

  • anticancer drug metabolism
  • personalized medicine
  • drug interactions
  • therapeutic efficacy
  • drug safety
  • pharmacogenomics

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Published Papers (1 paper)

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Research

19 pages, 2069 KB  
Article
Comparison of the Effect of the Combination of Sodium Valproate and Sodium Dichloroacetate on the Expression of SLC12A2, SLC12A5, CDH1, CDH2, EZH2, and GFAP in Primary Female Glioblastoma Cells with That of Temozolomide
by Dovydas Gečys, Laimis Akramas, Aidanas Preikšaitis, Ingrida Balnytė, Arūnas Vaitkevičius, Julija Šimienė and Donatas Stakišaitis
Pharmaceutics 2025, 17(9), 1161; https://doi.org/10.3390/pharmaceutics17091161 - 4 Sep 2025
Cited by 1 | Viewed by 1287
Abstract
The search for an effective treatment for adult high-grade glioblastoma (GBM) remains urgent. Background/Objectives: The study aimed to determine the expression of carcinogenesis-related genes, such as SLC12A2, SLC12A5, CDH1, CDH2, EZH2, and GFAP, in primary glioblastoma [...] Read more.
The search for an effective treatment for adult high-grade glioblastoma (GBM) remains urgent. Background/Objectives: The study aimed to determine the expression of carcinogenesis-related genes, such as SLC12A2, SLC12A5, CDH1, CDH2, EZH2, and GFAP, in primary glioblastoma (WHO Grade IV; IDH-wild-type) cells from three adult women: GBM5-1, GBM5-2F, and GBM5-3F. Methods: The impact of the combination of sodium valproate and sodium dichloroacetate (2 mM NaVPA–3 mM NaDCA) on the expression of these genes was determined and compared with the effects of 50 µM temozolomide after 24 h of treatment. Results: 2 mM NaVPA–3 mM NaDCA, as well as temozolomide, had individual impacts on the SLC12A2, SLC12A5, CDH1, CDH2, EZH2, and GFAP expressions of tested GBM5-1, GBM5-2F, and GBM5-3F primary cells of female GBM patients. Conclusions: The combination of 2 mM NaVPA–3 mM NaDCA may have an advantage in antitumor activity and may be more effective than TMZ; however, the effect is individual. Full article
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