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Pharmaceutics
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Phytochemicals and Bioactive Compound-Based Pharmaceutical Formulations in Health and Disease:...
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Phytochemicals and Bioactive Compound-Based Pharmaceutical Formulations in Health and Disease: From Mechanisms to Therapeutic Applications

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Physical Pharmacy and Formulation".

Deadline for manuscript submissions: 30 November 2026 | Viewed by 1403

Special Issue Editor

Dr. Lucas Fornari Laurindo

E-Mail Website
Guest Editor
Division of Cellular Growth, Hemodynamic and Homeostasis Disorders, Graduate Program in Medical Sciences, Faculdade de Medicina, Universidade de São Paulo (USP), São Paulo 01246-903, SP, Brazil
Interests: phytochemicals; bioactive compounds; functional foods; natural products; anticancer activity; metabolic health; metabolomics; mechanisms of action; pharmacokinetics; antioxidant activity; anti-inflammatory effects; nutraceuticals; translational research; personalized nutrition; systems biology
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Phytochemicals and other naturally derived bioactive compounds continue to attract significant attention for their potential roles in the prevention and treatment of various diseases. These compounds—ranging from polyphenols, flavonoids, and alkaloids to terpenes and saponins—have demonstrated diverse biological activities, including antioxidant, anti-inflammatory, antimicrobial, anticancer, neuroprotective, and cardioprotective effects. Understanding their mechanisms of action, pharmacokinetics, delivery systems, and clinical potential is essential for translating these natural products into effective therapeutic strategies. This Special Issue aims to bring together original research articles, reviews, and short communications that explore the extraction, characterization, biological activity, formulation, and therapeutic potential of phytochemicals and other bioactive compounds. Contributions may address molecular mechanisms, in vitro and in vivo studies, novel delivery systems, synergistic effects with conventional drugs, and clinical perspectives. We welcome multidisciplinary approaches from pharmacology, pharmaceutics, biochemistry, molecular biology, and related fields to deepen our understanding of how natural compounds can contribute to human health and disease management.

Dr. Lucas Fornari Laurindo
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pharmaceutics is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • phytochemicals and bioactive compounds
  • pharmaceutical formulations
  • therapeutics
  • delivery systems
  • pharmacokinetics
  • in vitro and in vivo studies

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Published Papers (1 paper)

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Research

18 pages, 3647 KB  
Article
Colchicine Suppresses Adipogenic Differentiation of Mesenchymal Stem Cells: Implications for Bone Adiposity Control
by Miriam López-Fagúndez, María Piñeiro-Ramil, Andrés Pazos-Pérez, María Guillán-Fresco, Verónica López, Djedjiga Ait Eldjoudi, Susana Belén Bravo-López, Alberto Jorge-Mora, Ana Alonso-Pérez and Rodolfo Gómez
Pharmaceutics 2026, 18(1), 119; https://doi.org/10.3390/pharmaceutics18010119 - 16 Jan 2026
Viewed by 1012
Abstract
Background: Gout is an inflammatory arthritis associated with increased bone anabolism and a higher risk of ectopic bone formation. Colchicine, used to prevent and treat acute gouty flares, inhibits microtubule polymerization and has been described to promote osteoblastogenesis. In bone disorders such [...] Read more.
Background: Gout is an inflammatory arthritis associated with increased bone anabolism and a higher risk of ectopic bone formation. Colchicine, used to prevent and treat acute gouty flares, inhibits microtubule polymerization and has been described to promote osteoblastogenesis. In bone disorders such as osteoporosis, disruption of the osteoblast–adipocyte balance contributes to pathology, yet no therapies directly target bone marrow adiposity. Thus, we decided to investigate the impact of colchicine on the osteoblast-adipocyte balance. Methods: C3H10T1/2 mesenchymal stem cells were differentiated to both cell fates in the presence or absence of colchicine. Differentiation was assessed by studying differentiation phenotypes as well as adipocytic and osteoblastic marker genes. Disrupting microtubule homeostasis through stathmin (STMN1) silencing was employed to mimic colchicine effects on differentiation. Proteomic analysis was performed to gain further insight into colchicine’s effects on adipogenesis. Results: Colchicine promoted transcriptional changes consistent with osteoblastogenic commitment and inhibited adipogenesis, as evidenced by reduced intracellular lipid accumulation and downregulation of adipogenic marker genes. These effects were observed following both continuous and transient exposure (median fold change across adipogenic markers 0.41 and 0.59, respectively). Consistent with colchicine-induced microtubule destabilisation, microtubule disruption by STMN1 silencing also suppressed adipogenic differentiation (median fold change = 0.66), suggesting that colchicine’s anti-adipogenic effect may be due to its impact on the cytoskeleton. Conclusions: These findings indicate that colchicine can suppress adipogenic differentiation while favouring osteoblast commitment in mesenchymal stem cells. Although further validation in relevant preclinical models is required, its efficacy following transient exposure supports the exploration of site-specific strategies that limit systemic toxicity. Full article
(This article belongs to the Special Issue Phytochemicals and Bioactive Compound-Based Pharmaceutical Formulations in Health and Disease: From Mechanisms to Therapeutic Applications)
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