Natural Macromolecule-Based Nanocarriers for Drug Delivery

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Drug Delivery and Controlled Release".

Deadline for manuscript submissions: closed (31 May 2025) | Viewed by 818

Special Issue Editor

School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China
Interests: novel drug delivery systems; pharmaceutical nanotechnology, and multifunctional nanomaterials for controlled drug delivery
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Natural macromolecules, including polysaccharides, proteins, nucleic acids, and lipids, are natural sources of biopolymeric materials which are not only biocompatible and biofunctional but they also have easily modified active groups in their structure that are highly effective in establishing fabricating nanocarriers for drug delivery. Natural macromolecules enable the construction of a wide variety of multifunctional drug delivery systems. They can be directly linked with drugs to form drug–polymer systems, prepared into nanoparticle encapsulated drugs and modified on the surface of various nanoparticles.

This Special Issue aims to provide a scientific platform for scientists to highlight recent advances in natural macromolecules-based drug delivery. In this Special Issue of Pharmaceutics, we invite authors to submit original research articles or reviews. Research areas may include, but are not limited to, the following topics: nanocarrier synthesis, mechanism research, theoretical developments, controlled release, targeted delivery, and molecule role in delivery.

I look forward to receiving your contributions.

Dr. Lipeng Qiu
Guest Editor

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Keywords

  • macromolecules
  • polysaccharides
  • proteins
  • nucleic acids
  • lipids
  • nanocarrier
  • drug delivery
  • targeted delivery
  • controlled release

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Published Papers (1 paper)

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Research

14 pages, 9175 KiB  
Article
Amphiphilic Celecoxib-Polysaccharide Delivery System for Enhanced Colon-Targeted Colitis Therapy
by Qiao Qiao, Xian Wan, Jie Li, Weijun Chen, Enxuan Li, Lipeng Qiu and Huiming Tu
Pharmaceutics 2025, 17(4), 511; https://doi.org/10.3390/pharmaceutics17040511 - 12 Apr 2025
Viewed by 471
Abstract
Background: Ulcerative colitis (UC), a subtype of chronic inflammatory bowel disease (IBD), is primarily treated with oral medications to reduce inflammation and alleviate symptoms. Celecoxib (CXB) is an attractive candidate for UC; however, its limited solubility and low bioavailability pose significant challenges [...] Read more.
Background: Ulcerative colitis (UC), a subtype of chronic inflammatory bowel disease (IBD), is primarily treated with oral medications to reduce inflammation and alleviate symptoms. Celecoxib (CXB) is an attractive candidate for UC; however, its limited solubility and low bioavailability pose significant challenges to its clinical application. Methods: We reported a novel chondroitin sulfate A–Celecoxib (CSA-CXB) polymeric nanoprodrug to address the limited solubility and low bioavailability of CXB. CXB was conjugated to chondroitin sulfate A (CSA) via succinic anhydride (SA) and ethylenediamine to prepare CSA-CXB polymers, which can self-assemble into nanoparticle structural prodrugs in aqueous condition. We investigated the stability, blood compatibility, and responsiveness of the nanoparticles. The ability of the nanoparticles to treat UC in vitro and in vivo was then evaluated. Results: The CSA-CXB nanoprodrug was spherical with a mean particle size of 188.4 ± 2.2 nm, a zeta potential of −22.9 ± 0.1 mV, and sustained drug release behavior. Furthermore, CSA-CXB exhibited remarkable antioxidant and anti-inflammatory effects, as it can significantly increase the free radical scavenging rate and reduce the expression level of ROS, TNF-α, IL-6, nitric oxide (NO), and COX-2 protein in vitro. In vivo results demonstrated that CSA-CXB targeted the mice’s colon efficiently mitigate UC symptoms by inhibiting the expression of inflammatory cytokine. Conclusions: The CSA-CXB nanoprodrug can improve the therapeutic impact of CXB, and has potential as a new preparation for a clinical UC treatment nanoprodrug. Full article
(This article belongs to the Special Issue Natural Macromolecule-Based Nanocarriers for Drug Delivery)
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