Stimuli-Responsive Materials and Their Biomedical Applications

A special issue of Journal of Functional Biomaterials (ISSN 2079-4983).

Deadline for manuscript submissions: closed (30 September 2023) | Viewed by 1410

Special Issue Editor

School of Life Sciences and Health Engineering, Jiangnan University, Wuxi 214122, China
Interests: drug delivery; gene therapy; nanomedicine; controlled release; functional polymers; biomedical materials

Special Issue Information

Dear Colleagues,

Stimuli-responsive materials have been widely studied in biomedical applications. They are able to sense one or more environmental “triggers” (e.g., pH, redox, temperature, light, reactive oxygen species, enzyme, glucose, ionic strength, and electric and magnetic fields) to subsequently change their intrinsic physical or chemical properties. Therefore, these stimuli-responsive materials have attracted major attention as smart materials in drug delivery, tissue engineering, biosensing, bioseparation, immobilized biocatalysis, diagnostics, and many other systems.

This Special Issue will host papers related to recent developments in the field of biomedical applications of stimuli-responsive materials. Topics will include but not be limited to microenvironment-responsive materials, field-responsive materials, biologically responsive materials, organic materials, inorganic materials, drug delivery systems, tissue engineering, imaging, and diagnostics. In this regard, I would like to invite authors to contribute research articles and review papers on these topics.

Dr. Lipeng Qiu
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Journal of Functional Biomaterials is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2700 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • stimuli-responsive materials
  • drug delivery
  • nanomaterials
  • responsive polymers
  • tumor treatment
  • biomedical engineering

Published Papers (1 paper)

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Research

15 pages, 22293 KiB  
Article
GSH-Activatable Metal-Phenolic Networks for Photothermal-Enhanced Chemotherapy and Chemodynamic Therapy
by Weijun Chen, Meiyang Yang, Jie Li, Zhilan Chen, Lefei Hu, Jiannan Zhang, Liangyu Cai, Lipeng Qiu and Jinghua Chen
J. Funct. Biomater. 2023, 14(9), 436; https://doi.org/10.3390/jfb14090436 - 23 Aug 2023
Viewed by 1066
Abstract
Chemotherapy (CT) plays an important role in the antitumor process, but the unsatisfactory therapeutic efficacy and the obvious toxic side effects of CT seriously restrict its application. To overcome the limitations of CT, the strategy of chemotherapy enhanced by chemodynamic therapy (CDT) and [...] Read more.
Chemotherapy (CT) plays an important role in the antitumor process, but the unsatisfactory therapeutic efficacy and the obvious toxic side effects of CT seriously restrict its application. To overcome the limitations of CT, the strategy of chemotherapy enhanced by chemodynamic therapy (CDT) and photothermal therapy (PTT) has been considered a promising approach to improve the anticancer effect. Herein, a novel GSH-activatable Cu2+-Quercetin network (QC) was synthesized via a convenient strategy to load Au nanoparticles (NPs) and DOX, named QCDA, for the synergistic therapy of CT/CDT/PTT. The results showed that QCDA exhibited GSH-sensitive degradation and “cargos” release in cancer cells, and then PTT and CDT caused by Au NPs and Cu+ significantly enhanced the CT effect of DOX and Quercetin on anticancer. More importantly, the PTT and depleted GSH accelerated the Fenton-like ionization process resulting in facilitating the CDT efficiency. Collectively, the multi-mode synergistic strategy of CT/CDT/PTT, which showed an excellent therapeutic effect, maybe a potential therapeutic pathway for anticancer. Full article
(This article belongs to the Special Issue Stimuli-Responsive Materials and Their Biomedical Applications)
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