Cell-Mediated Delivery Systems

A special issue of Pharmaceutics (ISSN 1999-4923). This special issue belongs to the section "Gene and Cell Therapy".

Deadline for manuscript submissions: 30 June 2025 | Viewed by 940

Special Issue Editors


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Guest Editor
Institute of Clinical Physiology (IFC), National Research Council of Italy (CNR), Via Fiorentina 1, 53100 Siena, Italy
Interests: epigenetics; drug delivery; MAPKs signaling; cancer

E-Mail Website
Guest Editor
Institute of Clinical Physiology (IFC), National Research Council of Italy (CNR), Via Fiorentina 1, 53100 Siena, Italy
Interests: neuroscience; drug delivery; cancer; preclinical studies

Special Issue Information

Dear Colleagues,

Developing novel therapeutics to combat diseases remains a major challenge. However, the systemic administration of drugs is often associated with several limitations, including poor bioavailability and a lack of target specificity. These factors typically require the use of higher dosages, which can lead to adverse side effects. The development of drug delivery systems enabling precise targeting and enhancing drug safety and efficacy is essential in overcoming these issues. In this regard, cell-based drug carriers are the ideal tools, due to their biocompatibility, low immunogenicity, prolonged circulation, and ability to reach virtually any body region. Moreover, they can be engineered to enable precise targeting.

This Special Issue will showcase the latest advancements in cell-based drug delivery systems and promote their further development. We encourage researchers to contribute by submitting original articles or reviews, to drive further progress in this important research field.

We look forward to receiving your contributions.

Dr. Monia Taranta
Dr. Lisa Gherardini
Guest Editors

Manuscript Submission Information

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Keywords

  • cell-targeted drug delivery
  • cell-mediated drug transport
  • targeted therapy
  • cellular uptake
  • nanocarriers for drug delivery

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Published Papers (1 paper)

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Review

26 pages, 2176 KiB  
Review
Extracellular Vesicles as Precision Delivery Systems for Biopharmaceuticals: Innovations, Challenges, and Therapeutic Potential
by Sidhesh Mohak and Zsolt Fabian
Pharmaceutics 2025, 17(5), 641; https://doi.org/10.3390/pharmaceutics17050641 - 12 May 2025
Cited by 1 | Viewed by 567
Abstract
Unlike traditional small-molecule agents, biopharmaceuticals, like synthetic RNAs, enzymes, and monoclonal antibodies, are highly vulnerable to environmental conditions. Preservation of their functional integrity necessitates advanced delivery methods. Being biocompatible, extracellular vesicles (EVs) gained attention as a promising system for delivering biopharmaceuticals, addressing challenges [...] Read more.
Unlike traditional small-molecule agents, biopharmaceuticals, like synthetic RNAs, enzymes, and monoclonal antibodies, are highly vulnerable to environmental conditions. Preservation of their functional integrity necessitates advanced delivery methods. Being biocompatible, extracellular vesicles (EVs) gained attention as a promising system for delivering biopharmaceuticals, addressing challenges related to the stability and efficacy of sensitive therapeutic molecules. Indeed, EVs can cross biological barriers like the blood–brain barrier, delivering therapeutic cargo to tissues that are traditionally difficult to reach. Recent innovations in surface modification technologies, including ligand and antibody attachment, have further enhanced EVs’ targeting capabilities, making them particularly effective in personalized medicine. Here, we review the versatile suitability of EVs for being next-generation delivery vehicles of biopharmaceuticals, including current standings, practical challenges, and possible future directions of the technology. Full article
(This article belongs to the Special Issue Cell-Mediated Delivery Systems)
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