Novel Therapeutic and Drug Delivery Strategies for Neurodegenerative Diseases

Dear Colleagues,

The multifactorial nature of neurodegenerative disorders and the limited availability of options as true disease-modifying therapies warrant the identification of novel therapeutic strategies against these diseases. The future of successful therapeutic intervention relies on effective drug development and delivery strategies for carefully investigated disease targets. Multipronged approaches targeting multiple disease targets have also offered promising therapeutic outcomes. A significant impediment to developing effective treatment strategies is posed by the limited permeability of effective molecules across the blood–brain barrier. Advances in the field of CNS drug delivery methods have offered promising results in recent years, and provide hope for successful clinical translation. Such basic and translational research endeavors aiming to gain a deeper understanding of disease pathogenesis, and attempting effective engagement of these mechanisms to delay disease onset or progression could result in much-needed breakthroughs. For this Special Issue, we invite research contributions and review articles in the field of neurodegenerative disorders that describe the identification of novel targets, strategies for target engagement, novel approaches for the effective delivery of therapeutics to the brain, and the development of novel formulations. This summary of research discoveries could serve as a valuable resource for future therapeutic development efforts in the field of neurodegenerative disorders.

Dr. Swati S. More
Guest Editor

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• drug design
• drug discovery
• drug repurposing
• brain delivery
• drug carrier
• drug formulation
• novel target identification