Special Issue "Virulence Factors of Periodontal Pathogens: Secretion, Function and Interaction with Host Immune Responses"

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 30 November 2020.

Special Issue Editors

Prof. Dr. Jan Potempa
Guest Editor
1. Department of Oral Immunity and Infectious Diseases, University of Louisville School of Dentistry, Louisville, KY, USA
2. Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
Interests: proteolytic enzymes and their inhibitors in homeostasis and disease and molecular bases of virulence of periodontal pathogens and their relation to systemic diseases
Dr. Anna Maria Łasica
Guest Editor
Department of Bacterial Genetics, Institute of Microbiology, Faculty of Biology, University of Warsaw, Warsaw, Poland
Interests: enteropathogens; oral pathogens; molecular microbiology; T9SS; virulence

Special Issue Information

Dear Colleagues,

Recent methodological advances have accelerated research on periodontitis and the role of the dysbiotic microbiota on the tooth surface below the gum line in the development and maintenance of chronic inflammation of the periodontium. Concurrently, we have learned a lot about communication between bacteria recently in the dental plaque community and how they can corrupt host immune responses. Additionally, our knowledge of mechanisms causing erosion of the periodontium has increased exponentially. In all respects, Porphyromonas gingivalis, together with established and emerging periodontal pathogens, is at the center of the pathobiology of periodontitis. Therefore, the purpose of this Special Issue is to present major recent advances in investigations of different host and bacterial aspects of the disease emanating from several ground-braking findings in periodontal pathogens research in the last few years.

Potential topics include but are not limited to:

 (i) Structural and functional characterization of the novel type IX secretion system (T9SS) used by periodontal pathogens to secrete their proteinaceous virulence factors;

(ii) Advances in characterization of virulence factors structure on the atomic structure level; 

(iii) Understanding molecular mechanisms of dysbiotic community development on the tooth surface;

(iv) Elucidation of host signaling pathways manipulated by P. gingivalis and other periodontal pathogens;

(v) Implication of P. gingivalis as a potentially causative factor in diseases such as esophageal cancer, rheumatoid arthritis, Alzheimer’s disease, and other systemic diseases associated with periodontitis; 

(vi) Identification and characterization of new targets for development of novel strategies to prevent/treat periodontitis.

Such assembly of articles in one issue would be unique among the existing literature on oral pathogens and their role in pathogenesis of periodontitis and associated systemic diseases.

Prof. Dr. Jan Potempa
Dr. Anna Maria Łasica
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • periodontitis
  • T9SS
  • secretion
  • gingipains
  • therapy
  • cargo proteins
  • proteases
  • virulence factors
  • Porphyromonas gingivalis
  • Tannerella forsythia
  • Filifactor alocis
  • pathogenesis
  • host–pathogen interactions
  • innate immune system
  • complement
  • antigen
  • biofilm
  • dental plaque
  • oral pathogens

Published Papers

This special issue is now open for submission.
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