Special Issue "Virulence Factors of Periodontal Pathogens: Secretion, Function and Interaction with Host Immune Responses"
A special issue of Pathogens (ISSN 2076-0817). This special issue belongs to the section "Immunological Responses and Immune Defense Mechanisms".
Deadline for manuscript submissions: closed (31 May 2021).
2. Department of Microbiology, Faculty of Biochemistry, Biophysics and Biotechnology, Jagiellonian University, Krakow, Poland
Interests: proteolytic enzymes and their inhibitors in homeostasis and disease and molecular bases of virulence of periodontal pathogens and their relation to systemic diseases
Recent methodological advances have accelerated research on periodontitis and the role of the dysbiotic microbiota on the tooth surface below the gum line in the development and maintenance of chronic inflammation of the periodontium. Concurrently, we have learned a lot about communication between bacteria recently in the dental plaque community and how they can corrupt host immune responses. Additionally, our knowledge of mechanisms causing erosion of the periodontium has increased exponentially. In all respects, Porphyromonas gingivalis, together with established and emerging periodontal pathogens, is at the center of the pathobiology of periodontitis. Therefore, the purpose of this Special Issue is to present major recent advances in investigations of different host and bacterial aspects of the disease emanating from several ground-braking findings in periodontal pathogens research in the last few years.
Potential topics include but are not limited to:
(i) Structural and functional characterization of the novel type IX secretion system (T9SS) used by periodontal pathogens to secrete their proteinaceous virulence factors;
(ii) Advances in characterization of virulence factors structure on the atomic structure level;
(iii) Understanding molecular mechanisms of dysbiotic community development on the tooth surface;
(iv) Elucidation of host signaling pathways manipulated by P. gingivalis and other periodontal pathogens;
(v) Implication of P. gingivalis as a potentially causative factor in diseases such as esophageal cancer, rheumatoid arthritis, Alzheimer’s disease, and other systemic diseases associated with periodontitis;
(vi) Identification and characterization of new targets for development of novel strategies to prevent/treat periodontitis.
Such assembly of articles in one issue would be unique among the existing literature on oral pathogens and their role in pathogenesis of periodontitis and associated systemic diseases.
Prof. Dr. Jan Potempa
Dr. Anna Maria Łasica
Manuscript Submission Information
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- cargo proteins
- virulence factors
- Porphyromonas gingivalis
- Tannerella forsythia
- Filifactor alocis
- host–pathogen interactions
- innate immune system
- dental plaque
- oral pathogens