Special Issue "The Twists and Turns of Pathogenic Spirochetes: Novel Insights for Prevention, Diagnosis and Treatment"

A special issue of Pathogens (ISSN 2076-0817).

Deadline for manuscript submissions: 31 May 2021.

Special Issue Editor

Dr. Ryan O. M. Rego
Guest Editor
1. Institute of Parasitology, Biology Centre, Academy of Sciences of Czech Republic, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
2. Faculty of Science, University of South Bohemia, Branisovska 31, 370 05 Ceske Budejovice, Czech Republic
Interests: Bacterial genetics; Tick-borne diseases; Vaccines; Diagnostics; Arthropod innate immunity; Epidemiology

Special Issue Information

Dear Colleagues

Spirochetes are an intriguing group of bacteria. Appearing very diverse when looking at their habitat, ecology, and in many instances their infectivity of vertebrate and non-vertebrate hosts, they are often considered together because of their similar cellular morphologies. They usually are long and thin and can be shaped like flat waves, helices, or more irregular morphologies. As mentioned, a large number of members of this group are known to be pathogens causing diseases worldwide such as Lyme disease, relapsing fever, syphilis, brachyspiral dysentery, and leptospirosis. They are all very different in their genomes which can be very segmented as in the Lyme disease Borrelia that have linear and circular plasmids besides the chromosome to a single circular genome in Treponema spp., the pathogen responsible for syphilis. Besides being unique among bacteria in their motility, which enables them to move within the tissue of their hosts, they also depend on a host of outer surface proteins for evasion of the innate and adaptive immune response within the host.

Spirochetes causing Lyme disease, relapsing fever, and leptospirosis are zoonotic in nature, with the first two mentioned having a tick host, which acts as a vector, within their zoonotic cycle. The identification and description of the adaptations required for pathogenic spirochetes to be able to enter, disseminate, persist, and infect is still very new, interesting, and challenging. An increased understanding in this field is fundamental to the discovery and implementation of strategies for better diagnosis, treatment, and prevention.

I would like to invite colleagues investigating any of the pathogenic spirochetes within the areas of their ecology, genetics, genomics, immunology, detection, public health, and vaccine development to submit their manuscripts to this Special Issue in the form of original research and reviews.

Dr. Ryan O. M. Rego
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 1400 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • Borrelia
  • Leptospira
  • Treponema
  • Brachyspira
  • Leptospirosis
  • Syphilis
  • Relapsing fever
  • Lyme disease
  • Tick
  • Zoonotic diseases
  • Ecology
  • Host–pathogen Interactions
  • Public health

Published Papers

This special issue is now open for submission.
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