Special Issue "Neisseria gonorrhoeae Infections"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (30 June 2020) | Viewed by 13885
A printed edition of this Special Issue is available here.
Interests: antibiotic resistance; drug development; drug repurposing; clinical microbiology
Special Issues, Collections and Topics in MDPI journals
Gonorrhea is a sexually transmitted disease caused by the obligate human pathogen Neisseria gonorrhoeae. This Gram‐negative diplococcus is highly infective due to its virulence factors: pili, Por proteins, Opa proteins, Rmp proteins, lipooligosaccharides and IgA protease. The most common form of presentation in men is acute anterior urethritis, while gonococcal infection in women does not have specific symptoms. Although the prevailing view is that infections in women are mainly asymptomatic whereas infections in men are not, many studies show that asymptomatic infections are prevalent in both sexes.
More than 106 million new cases of gonorrhea are estimated to occur yearly worldwide. The highest incidence areas include Africa and the Western Pacific regions. Gonorrhea is primarily transmitted from an infected individual by direct human‐to‐human contact between the mucosal membranes of the urogenital tract, anal canal and the oropharynx, usually during sexual activities. Ever since sulphonamides were introduced to treat gonorrhea in the 1930s, gonococci have continuously shown an extraordinary ability to develop resistance to any antimicrobial introduced for treatment. Treatment is currently given empirically, without performing antimicrobial susceptibility tests. However, the increasing issue of drug‐resistant gonococci has leaded the scientific community to focus research in new drugs and alternative treatments, having obtained encouraging results. The diagnosis of gonorrhea is established by identification of N. gonorrhoeae in genital, rectal, pharyngeal or ocular secretions. N. gonorrhoeae can be detected by culture or nucleic acid amplification tests and, in some cases, Gram staining. Seeing as all attempts to develop a vaccine against gonococci have been unsuccessful, prevention and control of the disease relies completely on early diagnosis, accurate treatment and public health education.
The best knowledge of the molecular mechanisms of this bacterium will facilitate disease prevention, surveillance and control, improve diagnostics and may help to facilitate the development of effective vaccines or new therapeutics.
This Research Topic in Pathogens is dedicated to Neisseria gonorrhoeae Infections. We encourage the submission of original research and review articles, related to:
- Colonization and immune evasion
- Immunology response
- Antibiotic resistance mechanisms
- Antibiotic resistance
- Current treatment
- Prevention and control
We believe that the Research Topic will give an updated insight into the vibrant field of Neisseria gonorrhoeae, and hope it will serve the purpose to inspire new research activities.
Prof. Dr. María-Teresa Pérez-Gracia
Dr. Beatriz Suay-García
Manuscript Submission Information
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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Pathogens is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Neisseria gonorrhoeae
- antibiotic resistance