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To What Extent Should We Rely on Antibiotics to Reduce High Gonococcal Prevalence? Historical Insights from Mass-Meningococcal Campaigns

by 1,2
1
HIV/STI Unit, Institute of Tropical Medicine, 2000 Antwerp, Belgium
2
Division of Infectious Diseases and HIV Medicine, University of Cape Town, Anzio Road, Observatory 7700, South Africa
Pathogens 2020, 9(2), 134; https://doi.org/10.3390/pathogens9020134
Received: 15 January 2020 / Revised: 6 February 2020 / Accepted: 17 February 2020 / Published: 18 February 2020
(This article belongs to the Special Issue Neisseria gonorrhoeae Infections)
In the absence of a vaccine, current antibiotic-dependent efforts to reduce the prevalence of Neisseria gonorrhoeae in high prevalence populations have been shown to result in extremely high levels of antibiotic consumption. No randomized controlled trials have been conducted to validate this strategy and an important concern of this approach is that it may induce antimicrobial resistance. To contribute to this debate, we assessed if mass treatment in the related species, Neisseria meningitidis, was associated with the emergence of antimicrobial resistance. To this end, we conducted a historical review of the effect of mass meningococcal treatment programmes on the prevalence of N. meningitidis and the emergence of antimicrobial resistance. We found evidence that mass treatment programmes were associated with the emergence of antimicrobial resistance. View Full-Text
Keywords: Neisseria gonorrhoeae; AMR; Neisseria meningitides; commensal Neisseria Neisseria gonorrhoeae; AMR; Neisseria meningitides; commensal Neisseria
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Kenyon, C. To What Extent Should We Rely on Antibiotics to Reduce High Gonococcal Prevalence? Historical Insights from Mass-Meningococcal Campaigns. Pathogens 2020, 9, 134.

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