Special Issue "Listeria monocytogenes and Its Interactions with the Host"
A special issue of Pathogens (ISSN 2076-0817).
Deadline for manuscript submissions: closed (30 November 2017) | Viewed by 26537
The bacterium Listeria monocytogenes was first isolated in the 1920s by EGD Murray and colleagues, who identified it as a cause of mononuclear leukocytosis in rabbits. Since this discovery, L. monocytogenes has proven to be a remarkably important and impactful pathogen. In adult humans, L. monocytogenes causes infections that range from gastroenteritis to life-threatening sepsis and meningitis. This pathogen also can establish severe invasive infections of the placenta or neonate. L. monocytogenes infections can occur sporadically or in clusters associated with consumption of contaminated food products. In addition to its importance as a cause of human disease, L. monocytogenes has proven to also be a remarkably useful and tractable model pathogen. Early work by George Mackaness established powerful cell culture models and developed a reliable murine model of systemic Listeriosis. He and colleagues then used these powerful tools to define fundamental concepts of macrophage activation and cell-mediated immunity. More than 50 years later, L. monocytogenes remains amongst the most widely-used model pathogens and this pathogen continues to play an important role in studies that enlighten the field of immunology. With the development and application of genetic tools, many L. monocytogenes factors have been identified, mutated, and studied for their contributions to pathogenesis in cell culture and animal infections. Work with these wildtype and mutant L. monocytogenes strains continues to provide new insights into fundamental aspects of intracellular parasitism, cell biology, and cellular microbiology. Recent work has further explored the potential use of L. monocytogenes as a vector for delivery of antigens or other genes in the context of human vaccines and therapies. For this Special Issue of Pathogens, we invite you to submit a review article focused on an important aspect of L. monocytogenes and its interaction with host cells, model organisms, or human populations.
Prof. Dr. Laurel L. Lenz
Manuscript Submission Information
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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- immune response
- innate immunity
- adaptive immunity
- immune cells