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Pathogens 2018, 7(2), 55; https://doi.org/10.3390/pathogens7020055

Listeria Monocytogenes: A Model Pathogen Continues to Refine Our Knowledge of the CD8 T Cell Response

Department of Molecular Genetics & Microbiology, Center for Infectious Diseases, Stony Brook University, Stony Brook, NY 11790, USA
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Received: 22 April 2018 / Revised: 13 June 2018 / Accepted: 14 June 2018 / Published: 16 June 2018
(This article belongs to the Special Issue Listeria monocytogenes and Its Interactions with the Host)
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Abstract

Listeria monocytogenes (Lm) infection induces robust CD8 T cell responses, which play a critical role in resolving Lm during primary infection and provide protective immunity to re-infections. Comprehensive studies have been conducted to delineate the CD8 T cell response after Lm infection. In this review, the generation of the CD8 T cell response to Lm infection will be discussed. The role of dendritic cell subsets in acquiring and presenting Lm antigens to CD8 T cells and the events that occur during T cell priming and activation will be addressed. CD8 T cell expansion, differentiation and contraction as well as the signals that regulate these processes during Lm infection will be explored. Finally, the formation of memory CD8 T cell subsets in the circulation and in the intestine will be analyzed. Recently, the study of CD8 T cell responses to Lm infection has begun to shift focus from the intravenous infection model to a natural oral infection model as the humanized mouse and murinized Lm have become readily available. Recent findings in the generation of CD8 T cell responses to oral infection using murinized Lm will be explored throughout the review. Finally, CD8 T cell-mediated protective immunity against Lm infection and the use of Lm as a vaccine vector for cancer immunotherapy will be highlighted. Overall, this review will provide detailed knowledge on the biology of CD8 T cell responses after Lm infection that may shed light on improving rational vaccine design. View Full-Text
Keywords: Listeria monocytogenes; CD8 T cells; dendritic cells; T cell activation; expansion; differentiation; contraction; and memory formation; resident memory T cells; CD8 T cell-mediated protective immunity; vaccine; cancer immunotherapy Listeria monocytogenes; CD8 T cells; dendritic cells; T cell activation; expansion; differentiation; contraction; and memory formation; resident memory T cells; CD8 T cell-mediated protective immunity; vaccine; cancer immunotherapy
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Qiu, Z.; Khairallah, C.; Sheridan, B.S. Listeria Monocytogenes: A Model Pathogen Continues to Refine Our Knowledge of the CD8 T Cell Response. Pathogens 2018, 7, 55.

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