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Review

Multifaceted Defense against Listeria monocytogenes in the Gastro-Intestinal Lumen

by 1,* and 1,2,3,*
1
Immunology Program, Sloan Kettering Institute, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
2
Lucille Castori Center for Microbes Inflammation and Cancer, Molecular Microbiology Core Facility, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
3
Infectious Diseases Service, Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY 10065, USA
*
Authors to whom correspondence should be addressed.
Pathogens 2018, 7(1), 1; https://doi.org/10.3390/pathogens7010001
Received: 1 December 2017 / Revised: 18 December 2017 / Accepted: 20 December 2017 / Published: 22 December 2017
(This article belongs to the Special Issue Listeria monocytogenes and Its Interactions with the Host)
Listeria monocytogenes is a foodborne pathogen that can cause febrile gastroenteritis in healthy subjects and systemic infections in immunocompromised individuals. Despite the high prevalence of L. monocytogenes in the environment and frequent contamination of uncooked meat and poultry products, infections with this pathogen are relatively uncommon, suggesting that protective defenses in the general population are effective. In the mammalian gastrointestinal tract, a variety of defense mechanisms prevent L. monocytogenes growth, epithelial penetration and systemic dissemination. Among these defenses, colonization resistance mediated by the gut microbiota is crucial in protection against a range of intestinal pathogens, including L. monocytogenes. Here we review defined mechanisms of defense against L. monocytogenes in the lumen of the gastro-intestinal tract, with particular emphasis on protection conferred by the autochthonous microbiota. We suggest that selected probiotic species derived from the microbiota may be developed for eventual clinical use to enhance resistance against L. monocytogenes infections. View Full-Text
Keywords: Listeria monocytogenes; microbiota; colonization resistance Listeria monocytogenes; microbiota; colonization resistance
MDPI and ACS Style

Becattini, S.; Pamer, E.G. Multifaceted Defense against Listeria monocytogenes in the Gastro-Intestinal Lumen. Pathogens 2018, 7, 1. https://doi.org/10.3390/pathogens7010001

AMA Style

Becattini S, Pamer EG. Multifaceted Defense against Listeria monocytogenes in the Gastro-Intestinal Lumen. Pathogens. 2018; 7(1):1. https://doi.org/10.3390/pathogens7010001

Chicago/Turabian Style

Becattini, Simone, and Eric G. Pamer 2018. "Multifaceted Defense against Listeria monocytogenes in the Gastro-Intestinal Lumen" Pathogens 7, no. 1: 1. https://doi.org/10.3390/pathogens7010001

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