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Listeria monocytogenes: The Impact of Cell Death on Infection and Immunity

Department of Medical Microbiology and Immunology, School of Medicine and Public Health, University of Wisconsin-Madison, Madison, WI 53706, USA
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Pathogens 2018, 7(1), 8; https://doi.org/10.3390/pathogens7010008
Received: 30 November 2017 / Revised: 28 December 2017 / Accepted: 3 January 2018 / Published: 11 January 2018
(This article belongs to the Special Issue Listeria monocytogenes and Its Interactions with the Host)
Listeria monocytogenes has evolved exquisite mechanisms for invading host cells and spreading from cell-to-cell to ensure maintenance of its intracellular lifecycle. As such, it is not surprising that loss of the intracellular replication niche through induction of host cell death has significant implications on the development of disease and the subsequent immune response. Although L. monocytogenes can activate multiple pathways of host cell death, including necrosis, apoptosis, and pyroptosis, like most intracellular pathogens L. monocytogenes has evolved a series of adaptations that minimize host cell death to promote its virulence. Understanding how L. monocytogenes modulates cell death during infection could lead to novel therapeutic approaches. In addition, as L. monocytogenes is currently being developed as a tumor immunotherapy platform, understanding how cell death pathways influence the priming and quality of cell-mediated immunity is critical. This review will focus on the mechanisms by which L. monocytogenes modulates cell death, as well as the implications of cell death on acute infection and the generation of adaptive immunity. View Full-Text
Keywords: Listeria monocytogenes; cell death; necrosis; apoptosis; pyroptosis; cell-mediated immunity; CD8+ T-cells Listeria monocytogenes; cell death; necrosis; apoptosis; pyroptosis; cell-mediated immunity; CD8+ T-cells
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McDougal, C.E.; Sauer, J.-D. Listeria monocytogenes: The Impact of Cell Death on Infection and Immunity. Pathogens 2018, 7, 8.

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