Current Advances in Flavivirus Research

Dear Colleagues,

Infectious diseases have gained importance as a significant threat to public health following the recent outbreaks of arthropod-transmitted (arboviruses) in the Western hemisphere. Members of flavivirus genus are the most important arthropod-borne viruses causing disease in humans. This genus includes pathogens of public health importance, including the West Nile virus (WNV), Japanese encephalitis virus (JEV), dengue virus (DENV), and Zika virus (ZIKV). Flaviviruses continue to spread and cause human disease in new areas of the world. With the recent outbreaks of Zika and yellow fever virus infections, the interest in these arthropod-borne viruses is exceptionally high. In the last few years, genomic and molecular investigations have established a remarkable progress on the pathogenic mechanisms of flavivirus infections using in vitro and in vivo models. Despite tremendous research efforts, though, there are yet to be clinically approved vaccines or therapeutic treatments available to combat the flavivirus infections. The lack of specific therapeutics for flavivirus infection imparts a pressing need to identify the viral and host factors in flavivirus replication and disease outcome.

In this Special Issue, we aim to assemble a collection of research papers and reviews that highlight critical advancements in our understanding of flavivirus pathogenesis and countermeasure development. Of particular interest are the immune responses to flavivirus infection, virus–host cell interactions, vector–host interactions, novel discoveries in flavivirus pathogenesis, vaccine development, and antiviral development. We look forward to your submissions.

Dr. Mukesh Kumar
Dr. Ok Sarah Shin
Guest Editors

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