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Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes

Department of Biology, College of Arts and Sciences, Georgia State University, Atlanta, GA 30303, USA
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Pathogens 2019, 8(3), 148; https://doi.org/10.3390/pathogens8030148
Received: 20 August 2019 / Revised: 9 September 2019 / Accepted: 11 September 2019 / Published: 12 September 2019
(This article belongs to the Special Issue Current Advances in Flavivirus Research)
Flavivirus replication in host cells requires the formation of replication and assembly complexes on the cytoplasmic side of the endoplasmic reticulum (ER) membrane. These complexes consist of an ER membrane, viral proteins, and host proteins. Genome-wide investigations have identified a number of ER multiprotein complexes as vital factors for flavivirus replication. The detailed mechanisms of the role of ER complexes in flavivirus replication are still largely elusive. This review highlights the fact that the ER multiprotein complexes are crucial for the formation of flavivirus replication and assembly complexes, and the ER complexes could be considered as a target for developing successful broad-spectrum anti-flavivirus drugs. View Full-Text
Keywords: flavivirus; virus replication complex; endoplasmic reticulum; host factors flavivirus; virus replication complex; endoplasmic reticulum; host factors
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Rothan, H.A.; Kumar, M. Role of Endoplasmic Reticulum-Associated Proteins in Flavivirus Replication and Assembly Complexes. Pathogens 2019, 8, 148.

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