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The Role of Nutritional Interventions and Exercise for Weight Loss

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".

Deadline for manuscript submissions: 15 January 2026 | Viewed by 266

Special Issue Editors


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Guest Editor
School of Health Sciences, College of Health and Medicine, University of Tasmania, Launceston, TAS 7248, Australia
Interests: physical activity; obesity; weight management; body composition assessment
Special Issues, Collections and Topics in MDPI journals

E-Mail Website
Guest Editor
School of Health Sciences, College of Health & Medicine, University of Tasmania, Launceston, TAS 7250, Australia
Interests: nutrition and dietetics; exercise physiology; food nutritional balance; sports science and exercise; biomedical and clinical sciences; public health; health promotion allied health and rehabilitation science (not elsewhere classified)

Special Issue Information

Dear Colleagues,

Nutritional interventions and exercise play a crucial role in weight loss by addressing both energy intake and expenditure. Dietary modifications are fundamental as they influence metabolism, satiety, and overall health and well-being. Reducing energy intake while maintaining nutrient density—including adequate protein, fibre and healthy fats—helps reduce fat mass while preserving lean mass and increasing satiety. However, compliance to a habitual healthy diet that supports sustained weight management remains elusive for a large proportion of the population.

Regular lifestyle physical activity and structured exercise enhances weight loss by increasing energy expenditure and metabolic rate. Aerobic activities, including walking, cycling, and swimming, are important for energy expenditure, while resistance training preserves lean muscle mass and functional strength, critical for weight maintenance. Physical activity also helps promote hormonal balance, improve insulin sensitivity and reduce stress-related accumulation of excess body weight.

A combination of nutrition and exercise leads to more effective and sustainable weight management compared to either approach alone. Long-term adherence to healthy eating and activity behaviours is key. Stress management and sleep quality also impact weight regulation and body composition. A personalised approach to weight management that integrates dietary adjustments, physical activity engagement, exercise routines, and behavioural strategies may enable best outcomes for weight loss and overall health and well-being.

Given the continued global prevalence of obesity and chronic diseases, this Special Issue seeks novel investigations into the impact of nutritional and physical activity/exercise interventions—whether implemented independently or in combination—to improve body composition and overall health.

Prof. Dr. Andrew P. Hills
Prof. Dr. Nuala M. Byrne
Guest Editors

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Keywords

  • aerobic
  • body composition
  • diet
  • energy expenditure
  • exercise
  • nutrition
  • physical activity
  • resistance training
  • weight loss
  • weight maintenance
  • weight management

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Published Papers (1 paper)

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Research

15 pages, 614 KB  
Article
Effectiveness of FitterLife: A Community-Based Virtual Weight Management Programme for Overweight Adults
by Lixia Ge, Fong Seng Lim, Shawn Lin, Joseph Antonio De Castro Molina, Michelle Jessica Pereira, A. Manohari, Donna Tan and Elaine Tan
Nutrients 2026, 18(1), 17; https://doi.org/10.3390/nu18010017 - 19 Dec 2025
Abstract
Background: The high prevalence of overweight and obesity in Singapore necessitates scalable primary prevention strategies. This study evaluated the short-term effectiveness of FitterLife, a 12-week, digitally delivered, group-based behavioural weight management programme targeting at-risk adults without diabetes or hypertension in the community. Methods: [...] Read more.
Background: The high prevalence of overweight and obesity in Singapore necessitates scalable primary prevention strategies. This study evaluated the short-term effectiveness of FitterLife, a 12-week, digitally delivered, group-based behavioural weight management programme targeting at-risk adults without diabetes or hypertension in the community. Methods: In a retrospective matched cohort study, we compared 306 FitterLife participants (enrolled from October 2021 to January 2025) with 5087 controls identified from a population health data mart, matched on age, sex, ethnicity, and baseline body mass index (BMI). The primary outcome was achieving ≥5% weight loss or a ≥1 kg/m2 BMI reduction at 12 weeks. Programme effectiveness was analysed using propensity score matching (1:1) and inverse probability weighted regression. Mixed-effects models assessed weight/BMI trajectories and modified Poisson regression identified behavioural factors associated with success. Results: After matching, FitterLife participants were more likely to achieve the weight loss target than controls (45.7% vs. 13.7%, coefficient = 0.32, 95% confidence interval [CI]: 0.26–0.38) and were over three times as likely to succeed (Adjusted incidence rate ratio [aIRR] = 3.37, 95% CI: 2.87–3.93). The programme group showed significant reductions in weight (−2.23 kg, 95% CI: −2.57 to −1.90) and BMI (−0.86 kg/m2, 95% CI: −0.95 to −0.73) at the end of programme. Higher session attendance and improved behavioural factors were associated with success. Conclusions: FitterLife was effective in achieving clinically significant short-term weight loss in a real-world setting. The findings demonstrate the potential of a scalable, behavioural theory-informed, virtual group model as a viable primary prevention strategy within national chronic disease management efforts. Full article
(This article belongs to the Special Issue The Role of Nutritional Interventions and Exercise for Weight Loss)
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