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Nutrition, Genes, and Biological Pathways Influencing Metabolism and Obesity

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Obesity".

Deadline for manuscript submissions: 15 June 2026 | Viewed by 502

Special Issue Editor


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Guest Editor
Department of Health and Biomedical Sciences, The University of Texas Rio Grande Valley, Brownsville, TX 78520, USA
Interests: obesity; insulin resistance; metabolism; inflammation; stress; diabetes; nutrition; biomarkers; genotyping; gene expression; adipocytes; white adipose tissue; brown adipose tissue; mitochondria

Special Issue Information

Dear Colleagues,

It is well-established that diet and lifestyle play significant roles in the development of obesity and comorbidities across the globe. However, the interplay between genetic susceptibility to obesity and nutrient intake is an area of active investigation and a potential contributor to obesity risk. Obesity is a serious health concern that can lead to a number of metabolic and other health complications. These include metabolic syndrome, insulin resistance, diabetes, and cardiovascular disease. Adipose tissue, once considered merely a storage organ for lipids, is actually a dynamic endocrine tissue that responds to environmental cues (such as nutrients and dietary intake) as well as genetic variations affecting responses to nutrition. Regulation of gene expression in metabolic and obesity pathways in response to nutrition, genetics or nutrient-gene interactions has a significant impact on human health.

The scope of this Special Issue is to publish articles that investigate the role of nutrition and/or nutrigenomics (gene–nutrient–food interactions) in obesity and comorbidities such as metabolic syndrome, insulin resistance, diabetes, hypertension, and cardiovascular diseases. The Special Issue will provide the scientific community with the latest advances in exploring the relationships between nutrition, genes, and obesity as well as their comorbidities. This will enhance our understanding of the role of nutrition in human health.

Prof. Dr. Saraswathy Nair
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • diet-induced obesity
  • metabolic syndrome
  • insulin resistance
  • inflammation
  • diabetes
  • nutrition
  • diet
  • biomarkers
  • genotyping
  • gene expression
  • white adipose tissue
  • brown adipose tissue
  • nutrigenomics

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Published Papers (1 paper)

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Review

19 pages, 642 KB  
Review
How the Intake of Pulses May Impact Metabolic Disorders and Dementia Risk: A Narrative Review
by Lisa M. B. Salinas, Maricarmen Marroquin, Mariana Mendez, Isabel Omaña-Guzmán and Juan C. Lopez-Alvarenga
Nutrients 2025, 17(24), 3898; https://doi.org/10.3390/nu17243898 - 12 Dec 2025
Viewed by 261
Abstract
We present a narrative review focusing on pulses’ geographical origin and distribution, their impact on human evolution and history, and their influence on human health. Pulses, including dry peas, beans, and lentils, are renowned for their richness in chemical antioxidants. Despite containing antinutrients, [...] Read more.
We present a narrative review focusing on pulses’ geographical origin and distribution, their impact on human evolution and history, and their influence on human health. Pulses, including dry peas, beans, and lentils, are renowned for their richness in chemical antioxidants. Despite containing antinutrients, processing techniques preserve their health advantages. Epidemiological research has consistently demonstrated that the consumption of pulses is associated with favorable effects on metabolism. This evidence is further supported by molecular and clinical research, which has elucidated potential nutrigenomic mechanisms and effects on gut microbiota composition underlying their health benefits. However, the literature lacks randomized controlled clinical trials investigating the effects of pulses on health outcomes. Despite this limitation, our review provides valuable insights into the potential beneficial effects of pulses in ameliorating metabolic disorders and reducing the risk of dementia and Alzheimer’s disease. Acknowledging the current limitations, we identify areas for further research to generate additional evidence. Specifically, well-designed randomized controlled trials are needed to thoroughly assess the efficacy of pulses in preventing metabolic diseases. Addressing these research gaps will enhance our understanding of the health benefits associated with pulse consumption and facilitate evidence-based dietary recommendations to improve public health outcomes. Full article
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