The Role of Nutrients in Heart Failure: Prevention, Treatment and Life Quality Management

Dear Colleagues,

Heart failure (HF) is a complex syndrome responsible for high rates of death and hospitalization worldwide. It represents a relevant problem for patients, caregivers, and health care resources. From a pathophysiological perspective, HF is a multifaceted disease, characterized by progressive systemic involvement leading to multiorgan dysfunction.

Despite recent progress in term of therapeutic and interventional treatment, morbidity and mortality rates are still too high. The management of the nutritional sphere is crucial for HF prevention, prognosis, and life quality management. In this regard, the impact of several risk factors may be hampered by diet behavior and nutrient supplementation; in HF patients, myocardial energetic impairment is associated with oxidative stress and disease progression; multiorgan involvement, iron deficiency, and non-neoplastic cachexia are frequently found during the natural course of HF; and in patients with end-stage HF, the management of life quality represents a crucial aspect of palliative care.

To better examine the role of nutrients in different stages of HF spectrum and to provide evidence and perspectives, this Special Issue will focus on research regarding pathophysiological, molecular, and clinical aspects of the relationship of nutrients and HF. Specifically, original articles reporting completely new results or reviews of current literature on these aspects of the disease will be considered. The Special Issue will focus on both basic and translational research, as well as clinical evidence in order to achieve a complete comprehension of the connection of nutrients and HF, considering all the aspects of the HF spectrum.

Dr. Paolo Severino
Guest Editor

Manuscript Submission Information

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Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

• heart failure
• inflammation
• metabolic syndrome
• oxidative stress
• mitochondrial dysfunction
• depression/mood disorders
• vitamins
• non-neoplastic cachexia
• iron deficiency
• nutrients