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Nutrients
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Obesity, Bariatric Surgery and Bone Health
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Obesity, Bariatric Surgery and Bone Health

A special issue of Nutrients (ISSN 2072-6643). This special issue belongs to the section "Nutrition and Metabolism".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 4162

Special Issue Editor

Dr. Julien Paccou

E-Mail Website
Guest Editor
Department of Rheumatology, MABLab ULR 4490, CHU Lille, University of Lille, 59000 Lille, France
Interests: bone health following bariatric surgery; impact of obesity on bone metabolism; weight loss and musculoskeletal health; bone complications caused by sarcopenic obesity

Special Issue Information

Dear Colleagues,

 Until recently, obesity was believed to be protective against fracture. However, this paradigm has been challenged by numerous studies. For several reasons, the relationship between fat mass and bone is much more complex than previously thought: fracture occurrence in patients with obesity has a specific site distribution where falls play a strong role. It also requires a bone mineral density (BMD) assessment in subjects with obesity and in subjects submitted for a rapid decrease in body weight, which is a difficult task that is prone to bias.

 Advances in surgical procedures to treat morbid obesity have led to a tremendous increase in bariatric procedures worldwide. Many beneficial effects of these procedures have been reported, including improved diabetes status and survival. However, potential harmful consequences for bone health have been highlighted. In particular, the risk of fracture after bariatric procedures is increased.

 Our goal is to provide a comprehensive overview of this currently expanding field, incorporating all aspects of the complex management of bone health in patients with obesity, and after bariatric surgery.

 In this Special Issue, original research articles and reviews are welcome. Research areas may include (but are not limited to) novel insights into the pathogenesis and management of bone health in patients with obesity and bone deterioration following bariatric surgery.

 I look forward to receiving your contributions.

Dr. Julien Paccou
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Nutrients is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2900 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • bariatric surgery
  • obesit
  • sarcopenic obesity
  • weight loss
  • fractures
  • bone mineral density
  • bone turnover markers
  • bone health

Published Papers (2 papers)

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Research

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12 pages, 709 KiB  
Article
An Evaluation of the Implementation of the European Calcified Tissue Society Recommendations on the Prevention and Treatment of Osteoporosis Secondary to Bariatric Surgery
by Marion Courtalin, Hélène Verkindt, Naima Oukhouya Daoud, Nassima Ramdane, Bernard Cortet, François Pattou and Julien Paccou
Nutrients 2023, 15(4), 1007; https://doi.org/10.3390/nu15041007 - 17 Feb 2023
Viewed by 1441
Abstract
The purpose of this study was to evaluate the implementation of the European Calcified Tissue Society (ECTS) 2022 recommendations on the prevention and treatment of osteoporosis secondary to bariatric surgery. The ECTS 2022 recommendations were applied in a retrospective cohort of postmenopausal women [...] Read more.
The purpose of this study was to evaluate the implementation of the European Calcified Tissue Society (ECTS) 2022 recommendations on the prevention and treatment of osteoporosis secondary to bariatric surgery. The ECTS 2022 recommendations were applied in a retrospective cohort of postmenopausal women and men aged 50 years and older who were undergoing or had already undergone bariatric surgery. Osteoporosis medication was indicated if any of the following criteria were met: (i) history of recent (within 2 years) fragility fracture after the age of 40 years, (ii) BMD T score ≤ −2 at any of the sites of measurement, and (iii) FRAX® ≥ 20% for major osteoporotic fractures and/or ≥3% for hip fractures. Of the 170 patients (144 women, mean age 59 (55 to 63) years) included between February 2019 and March 2022, 33 were eligible for osteoporosis medication based on the ECTS 2022 recommendations, i.e., a prevalence of 19.6% [CI95%: 13.9%; 26.5%]. Most patients met the BMD T score ≤ −2 criterion (n = 25/170, 14.7% [CI95%: 9.7%; 20.9%]) and/or the history of recent fragility fracture criterion (n = 12/170, 7.1% [CI95%: 3.7%; 12.0%]). In this study, a fifth of our population was found to be eligible for osteoporosis medication after the application of the ECTS 2022 recommendations. Full article
(This article belongs to the Special Issue Obesity, Bariatric Surgery and Bone Health)
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Review

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21 pages, 12630 KiB  
Review
The Impact of Interventional Weight Loss on Bone Marrow Adipose Tissue in People Living with Obesity and Its Connection to Bone Metabolism
by Michaela Tencerova, Gustavo Duque, Kerensa M. Beekman, Alessandro Corsi, Jeroen Geurts, Peter H. Bisschop and Julien Paccou
Nutrients 2023, 15(21), 4601; https://doi.org/10.3390/nu15214601 - 29 Oct 2023
Cited by 4 | Viewed by 2100
Abstract
This review focuses on providing physicians with insights into the complex relationship between bone marrow adipose tissue (BMAT) and bone health, in the context of weight loss through caloric restriction or metabolic and bariatric surgery (MBS), in people living with obesity (PwO). We [...] Read more.
This review focuses on providing physicians with insights into the complex relationship between bone marrow adipose tissue (BMAT) and bone health, in the context of weight loss through caloric restriction or metabolic and bariatric surgery (MBS), in people living with obesity (PwO). We summarize the complex relationship between BMAT and bone health, provide an overview of noninvasive imaging techniques to quantify human BMAT, and discuss clinical studies measuring BMAT in PwO before and after weight loss. The relationship between BMAT and bone is subject to variations based on factors such as age, sex, menopausal status, skeletal sites, nutritional status, and metabolic conditions. The Bone Marrow Adiposity Society (BMAS) recommends standardizing imaging protocols to increase comparability across studies and sites, they have identified both water–fat imaging (WFI) and spectroscopy (1H-MRS) as accepted standards for in vivo quantification of BMAT. Clinical studies measuring BMAT in PwO are limited and have shown contradictory results. However, BMAT tends to be higher in patients with the highest visceral adiposity, and inverse associations between BMAT and bone mineral density (BMD) have been consistently found in PwO. Furthermore, BMAT levels tend to decrease after caloric restriction-induced weight loss. Although weight loss was associated with overall fat loss, a reduction in BMAT did not always follow the changes in fat volume in other tissues. The effects of MBS on BMAT are not consistent among the studies, which is at least partly related to the differences in the study population, skeletal site, and duration of the follow-up. Overall, gastric bypass appears to decrease BMAT, particularly in patients with diabetes and postmenopausal women, whereas sleeve gastrectomy appears to increase BMAT. More research is necessary to evaluate changes in BMAT and its connection to bone metabolism, either in PwO or in cases of weight loss through caloric restriction or MBS, to better understand the role of BMAT in this context and determine the local or systemic factors involved. Full article
(This article belongs to the Special Issue Obesity, Bariatric Surgery and Bone Health)
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